. . . . "Le lipide A est un constituant lipidique d'une endotoxine responsable de la toxicit\u00E9 des bact\u00E9ries \u00E0 Gram n\u00E9gatif. Il forme la plus interne des trois r\u00E9gions de la mol\u00E9cule de lipopolysaccharide (LPS ou endotoxine) et sa nature hydrophobe lui permet d'ancrer le LPS dans la membrane externe. Bien que ses effets toxiques puissent \u00EAtre particuli\u00E8rement n\u00E9fastes, la d\u00E9tection de lipide A par le syst\u00E8me immunitaire humain peut s'av\u00E9rer d\u00E9terminante pour l'activation de la r\u00E9ponse immunitaire aux infections \u00E0 Gram n\u00E9gatif et la r\u00E9ussite de cette r\u00E9ponse."@fr . . . . "Lipid A is a lipid component of an endotoxin held responsible for the toxicity of gram-negative bacteria. It is the innermost of the three regions of the lipopolysaccharide (LPS), also called endotoxin molecule, and its hydrophobic nature allows it to anchor the LPS to the outer membrane. While its toxic effects can be damaging, the sensing of lipid A by the immune system may also be critical for the onset of immune responses to gram-negative infection, and for the subsequent successful fight against the infection."@en . . "\u0644\u064A\u0628\u064A\u062F A"@ar . . . . . . . "\u30EA\u30D4\u30C9A\uFF08\u30EA\u30D4\u30C9\u30FB\u30A8\u30FC\u3001Lipid A\uFF09\u306F\u3001\u30B0\u30E9\u30E0\u9670\u6027\u7D30\u83CC\u306E\u6BD2\u6027\u306E\u539F\u56E0\u3067\u3042\u308B\u5185\u6BD2\u7D20\uFF08\u30A8\u30F3\u30C9\u30C8\u30AD\u30B7\u30F3\uFF09\u306E\u69CB\u6210\u6210\u5206\u3067\u3042\u308B\u3002\u30EA\u30DD\u591A\u7CD6\uFF08LPS, \u30A8\u30F3\u30C9\u30C8\u30AD\u30B7\u30F3\uFF09\u306E3\u3064\u306E\u9818\u57DF\u306E\u3046\u3061\u4E00\u756A\u5965\u306E\u90E8\u5206\u3067\u3042\u308A\u3001\u305D\u306E\u758E\u6C34\u6027\u306B\u3088\u3063\u3066LPS\u3092\u5916\u819C\u306B\u7E4B\u304E\u6B62\u3081\u3066\u3044\u308B\u3002\u30EA\u30D4\u30C9A\u81EA\u4F53\u306F\u6BD2\u6027\u3092\u793A\u3059\u304C\u3001\u30D2\u30C8\u306E\u514D\u75AB\u30B7\u30B9\u30C6\u30E0\u306B\u3088\u308B\u30EA\u30D4\u30C9A\u306E\u611F\u77E5\u306F\u3001\u30B0\u30E9\u30E0\u9670\u6027\u83CC\u306E\u611F\u67D3\u306B\u5BFE\u3059\u308B\u514D\u75AB\u5FDC\u7B54\u306E\u958B\u59CB\u306B\u91CD\u8981\u306A\u5F79\u5272\u3092\u679C\u305F\u3057\u3066\u3044\u308B\u3002LIPID MAPS\u306B\u3088\u308B\u5206\u985E\u3067\u7CD6\u8102\u8CEA\uFF08Saccharolipids\uFF09\u306B\u5206\u985E\u3055\u308C\u3066\u3044\u308B\u3002"@ja . . "\u30EA\u30D4\u30C9A"@ja . . . . . "\u064A\u0643\u0648\u0646 \u0644\u064A\u0628\u064A\u062F A \u0627\u0644\u062F\u0647\u0646\u064A (\u0628\u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629: Lipid A) \u0627\u0644\u062C\u0632\u0621 \u0627\u0644\u0630\u064A \u064A\u0645\u0644\u0643 \u062E\u0635\u0627\u0626\u0635 \u0627\u0644\u0630\u064A\u0641\u0627\u0646 \u0627\u0644\u062F\u0627\u062E\u0644\u064A (\u0628\u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629: endotoxin)\u060C \u0648\u064A\u0639\u062A\u0628\u0631 \u0627\u0644\u0645\u0633\u0624\u0648\u0644 \u0639\u0646 \u0633\u0645\u064A\u0629 \u0627\u0644\u0628\u0643\u062A\u064A\u0631\u064A\u0627 \u0633\u0627\u0644\u0628\u0629 \u0627\u0644\u062C\u0631\u0627\u0645. \u0648\u064A\u0634\u0643\u0644 \u0647\u0630\u0627 \u0627\u0644\u062F\u0647\u0646 \u0627\u0644\u0637\u0628\u0642\u0629 \u0627\u0644\u062F\u0627\u062E\u0644\u064A\u0629 (\u0627\u0644\u0639\u0645\u064A\u0642\u0629) \u0645\u0646 \u0627\u0644\u0637\u0628\u0642\u0627\u062A \u0627\u0644\u062B\u0644\u0627\u062B\u0629 \u0627\u0644\u0645\u0643\u0648\u0646\u0629 \u0644\u0644\u063A\u0634\u0627\u0621 \u0639\u062F\u064A\u062F \u0627\u0644\u0633\u0643\u0627\u0631\u064A\u062F \u0627\u0644\u062F\u0647\u0646\u064A (\u0628\u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629: lipopolysaccharide-\u0627\u062E\u062A\u0635\u0627\u0631\u0627\u064B LPS) \u0644\u0647\u0630\u0647 \u0627\u0644\u0623\u0646\u0648\u0627\u0639 \u0645\u0646 \u0627\u0644\u0628\u0643\u062A\u0631\u064A\u0627\u060C \u0648\u064A\u0639\u0631\u0641 \u0623\u064A\u0636\u0627 \u0628\u0627\u0644\u0630\u064A\u0641\u0627\u0646 \u0627\u0644\u062F\u0627\u062E\u0644\u064A\u060C \u062D\u064A\u062B \u0644\u0647 \u0637\u0628\u064A\u0639\u0629 \u0643\u0627\u0631\u0647 \u0644\u0644\u0645\u0627\u0621\u060C \u0648\u062A\u0633\u0645\u062D \u0647\u0630\u0647 \u0627\u0644\u0645\u064A\u0632\u0629 \u0644\u0627\u0631\u062A\u0628\u0627\u0637 \u0639\u062F\u064A\u062F \u0627\u0644\u0633\u0643\u0627\u0631\u064A\u062F \u0627\u0644\u062F\u0647\u0646\u064A LPS \u0625\u0644\u0649 \u0627\u0644\u063A\u0634\u0627\u0621 \u0627\u0644\u062E\u0627\u0631\u062C\u064A. \u0648\u0628\u0627\u0644\u0631\u063A\u0645 \u0645\u0646 \u0627\u0644\u0623\u0636\u0631\u0627\u0631 \u0627\u0644\u0633\u0627\u0645\u0629 \u0648\u0627\u0644\u0645\u0624\u062B\u0631\u0629 \u0644\u0647\u060C \u062A\u0639\u062A\u0628\u0631 \u062D\u0633\u0627\u0633\u064A\u0629 \u0627\u0644\u062C\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064A \u0644\u062F\u0649 \u0627\u0644\u0625\u0646\u0633\u0627\u0646 \u0644\u0644\u064A\u0628\u064A\u062F A \u0627\u0644\u062F\u0647\u0646\u064A \u0645\u0646 \u0623\u0647\u0645 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0644\u0644\u0627\u0633\u062A\u062C\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064A\u0629 \u0644\u0639\u062F\u0648\u0649 \u0628\u0643\u062A\u0631\u064A\u0627 \u0633\u0627\u0644\u0628\u0629 \u0627\u0644\u062C\u0631\u0627\u0645\u060C \u0648\u0645\u0646 \u0627\u0644\u0639\u0646\u0627\u0635\u0631 \u0623\u064A\u0636\u0627\u064B \u0627\u0644\u0646\u0627\u062C\u062D\u0629 \u0641\u064A \u0645\u0643\u0627\u0641\u062D\u0629 \u0627\u0644\u0639\u062F\u0648\u0649."@ar . "Lipide A"@fr . . . . . . . . . . . . . . . . . . "Lipid A"@en . . . . "1785386"^^ . "11981"^^ . . "\u8102\u8D28A\uFF08\u82F1\u8A9E\uFF1Alipid A\uFF09\u4E3A\u4E00\u79CD\u7CD6\u78F7\u8102\uFF0C\u7531D-\u6C28\u57FA\u8461\u8404\u7CD6\u53CC\u7CD6\u7EC4\u6210\u7684\u57FA\u672C\u9AA8\u67B6\uFF0C\u4E0D\u540C\u7EC6\u83CC\u9AA8\u67B6\u4E00\u81F4\u3002\u5177\u6709\u5185\u6BD2\u7D20\u6BD2\u6027\u4E0E\u751F\u7269\u5B66\u6D3B\u6027\u6210\u5206\uFF0C\u65E0\u79CD\u5C5E\u7279\u5F02\u6027\u3002"@zh . . . . "1089147211"^^ . . . "Lipid A is a lipid component of an endotoxin held responsible for the toxicity of gram-negative bacteria. It is the innermost of the three regions of the lipopolysaccharide (LPS), also called endotoxin molecule, and its hydrophobic nature allows it to anchor the LPS to the outer membrane. While its toxic effects can be damaging, the sensing of lipid A by the immune system may also be critical for the onset of immune responses to gram-negative infection, and for the subsequent successful fight against the infection."@en . "\u8102\u8D28A"@zh . . . . . . . "Le lipide A est un constituant lipidique d'une endotoxine responsable de la toxicit\u00E9 des bact\u00E9ries \u00E0 Gram n\u00E9gatif. Il forme la plus interne des trois r\u00E9gions de la mol\u00E9cule de lipopolysaccharide (LPS ou endotoxine) et sa nature hydrophobe lui permet d'ancrer le LPS dans la membrane externe. Bien que ses effets toxiques puissent \u00EAtre particuli\u00E8rement n\u00E9fastes, la d\u00E9tection de lipide A par le syst\u00E8me immunitaire humain peut s'av\u00E9rer d\u00E9terminante pour l'activation de la r\u00E9ponse immunitaire aux infections \u00E0 Gram n\u00E9gatif et la r\u00E9ussite de cette r\u00E9ponse. La capacit\u00E9 du LPS \u00E0 d\u00E9clencher une r\u00E9ponse immunitaire r\u00E9side essentiellement au niveau du lipide A. C'est un stimulant tr\u00E8s puissant du syst\u00E8me immunitaire, dont il active les cellules (monocytes, macrophages) \u00E0 des concentrations de quelques picogrammes par millilitre. Le lipide A se lie au r\u00E9cepteur Toll-like 4 (TLR4) pour activer une cascade de r\u00E9ponses immunitaires dont la production cytokines et de chimiokines telles que le facteur de n\u00E9crose tumorale-\u03B1 (TNF-\u03B1), l'interleukine-1\u03B2 (IL-1\u03B2 ), IL-6 et l'interf\u00E9ron-\u03B2 (IFN-\u03B2). \u00C0 concentration \u00E9lev\u00E9e dans l'organisme lors d'une infection \u00E0 Gram n\u00E9gatif, il peut d\u00E9clencher un syndrome de r\u00E9ponse inflammatoire syst\u00E9mique causant un \u00E9tat de choc pouvant entra\u00EEner la mort. Le lipide A consiste en deux r\u00E9sidus de glucosamine li\u00E9s \u00E0 des acides gras et contenant normalement un groupe phosphate sur chaque ose. On consid\u00E8re que la structure optimale pour l'activation du syst\u00E8me immunitaire contient six r\u00E9sidus d'acides gras. Quatre d'entre eux sont li\u00E9s directement aux r\u00E9sidus de glucosamine et ont des cha\u00EEnes aliphatiques \u03B2-hydroxyl\u00E9es longues de 10 \u00E0 16 atomes de carbone. Deux r\u00E9sidus d'acides gras suppl\u00E9mentaires sont souvent li\u00E9s aux groupes \u03B2-hydroxyle. Le lipide A d\u2019Escherichia coli, par exemple, poss\u00E8de quatre cha\u00EEnes d'acide gras hydroxyl\u00E9es en C14 li\u00E9es aux r\u00E9sidus de glucosamine et deux cha\u00EEnes suppl\u00E9mentaires en C12 et C14 li\u00E9es aux groupes hydroxyle."@fr . . . . . . . . . . . . . . . . . . . . "\u064A\u0643\u0648\u0646 \u0644\u064A\u0628\u064A\u062F A \u0627\u0644\u062F\u0647\u0646\u064A (\u0628\u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629: Lipid A) \u0627\u0644\u062C\u0632\u0621 \u0627\u0644\u0630\u064A \u064A\u0645\u0644\u0643 \u062E\u0635\u0627\u0626\u0635 \u0627\u0644\u0630\u064A\u0641\u0627\u0646 \u0627\u0644\u062F\u0627\u062E\u0644\u064A (\u0628\u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629: endotoxin)\u060C \u0648\u064A\u0639\u062A\u0628\u0631 \u0627\u0644\u0645\u0633\u0624\u0648\u0644 \u0639\u0646 \u0633\u0645\u064A\u0629 \u0627\u0644\u0628\u0643\u062A\u064A\u0631\u064A\u0627 \u0633\u0627\u0644\u0628\u0629 \u0627\u0644\u062C\u0631\u0627\u0645. \u0648\u064A\u0634\u0643\u0644 \u0647\u0630\u0627 \u0627\u0644\u062F\u0647\u0646 \u0627\u0644\u0637\u0628\u0642\u0629 \u0627\u0644\u062F\u0627\u062E\u0644\u064A\u0629 (\u0627\u0644\u0639\u0645\u064A\u0642\u0629) \u0645\u0646 \u0627\u0644\u0637\u0628\u0642\u0627\u062A \u0627\u0644\u062B\u0644\u0627\u062B\u0629 \u0627\u0644\u0645\u0643\u0648\u0646\u0629 \u0644\u0644\u063A\u0634\u0627\u0621 \u0639\u062F\u064A\u062F \u0627\u0644\u0633\u0643\u0627\u0631\u064A\u062F \u0627\u0644\u062F\u0647\u0646\u064A (\u0628\u0627\u0644\u0625\u0646\u062C\u0644\u064A\u0632\u064A\u0629: lipopolysaccharide-\u0627\u062E\u062A\u0635\u0627\u0631\u0627\u064B LPS) \u0644\u0647\u0630\u0647 \u0627\u0644\u0623\u0646\u0648\u0627\u0639 \u0645\u0646 \u0627\u0644\u0628\u0643\u062A\u0631\u064A\u0627\u060C \u0648\u064A\u0639\u0631\u0641 \u0623\u064A\u0636\u0627 \u0628\u0627\u0644\u0630\u064A\u0641\u0627\u0646 \u0627\u0644\u062F\u0627\u062E\u0644\u064A\u060C \u062D\u064A\u062B \u0644\u0647 \u0637\u0628\u064A\u0639\u0629 \u0643\u0627\u0631\u0647 \u0644\u0644\u0645\u0627\u0621\u060C \u0648\u062A\u0633\u0645\u062D \u0647\u0630\u0647 \u0627\u0644\u0645\u064A\u0632\u0629 \u0644\u0627\u0631\u062A\u0628\u0627\u0637 \u0639\u062F\u064A\u062F \u0627\u0644\u0633\u0643\u0627\u0631\u064A\u062F \u0627\u0644\u062F\u0647\u0646\u064A LPS \u0625\u0644\u0649 \u0627\u0644\u063A\u0634\u0627\u0621 \u0627\u0644\u062E\u0627\u0631\u062C\u064A. \u0648\u0628\u0627\u0644\u0631\u063A\u0645 \u0645\u0646 \u0627\u0644\u0623\u0636\u0631\u0627\u0631 \u0627\u0644\u0633\u0627\u0645\u0629 \u0648\u0627\u0644\u0645\u0624\u062B\u0631\u0629 \u0644\u0647\u060C \u062A\u0639\u062A\u0628\u0631 \u062D\u0633\u0627\u0633\u064A\u0629 \u0627\u0644\u062C\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064A \u0644\u062F\u0649 \u0627\u0644\u0625\u0646\u0633\u0627\u0646 \u0644\u0644\u064A\u0628\u064A\u062F A \u0627\u0644\u062F\u0647\u0646\u064A \u0645\u0646 \u0623\u0647\u0645 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0644\u0644\u0627\u0633\u062A\u062C\u0627\u0628\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u064A\u0629 \u0644\u0639\u062F\u0648\u0649 \u0628\u0643\u062A\u0631\u064A\u0627 \u0633\u0627\u0644\u0628\u0629 \u0627\u0644\u062C\u0631\u0627\u0645\u060C \u0648\u0645\u0646 \u0627\u0644\u0639\u0646\u0627\u0635\u0631 \u0623\u064A\u0636\u0627\u064B \u0627\u0644\u0646\u0627\u062C\u062D\u0629 \u0641\u064A \u0645\u0643\u0627\u0641\u062D\u0629 \u0627\u0644\u0639\u062F\u0648\u0649."@ar . . "\u30EA\u30D4\u30C9A\uFF08\u30EA\u30D4\u30C9\u30FB\u30A8\u30FC\u3001Lipid A\uFF09\u306F\u3001\u30B0\u30E9\u30E0\u9670\u6027\u7D30\u83CC\u306E\u6BD2\u6027\u306E\u539F\u56E0\u3067\u3042\u308B\u5185\u6BD2\u7D20\uFF08\u30A8\u30F3\u30C9\u30C8\u30AD\u30B7\u30F3\uFF09\u306E\u69CB\u6210\u6210\u5206\u3067\u3042\u308B\u3002\u30EA\u30DD\u591A\u7CD6\uFF08LPS, \u30A8\u30F3\u30C9\u30C8\u30AD\u30B7\u30F3\uFF09\u306E3\u3064\u306E\u9818\u57DF\u306E\u3046\u3061\u4E00\u756A\u5965\u306E\u90E8\u5206\u3067\u3042\u308A\u3001\u305D\u306E\u758E\u6C34\u6027\u306B\u3088\u3063\u3066LPS\u3092\u5916\u819C\u306B\u7E4B\u304E\u6B62\u3081\u3066\u3044\u308B\u3002\u30EA\u30D4\u30C9A\u81EA\u4F53\u306F\u6BD2\u6027\u3092\u793A\u3059\u304C\u3001\u30D2\u30C8\u306E\u514D\u75AB\u30B7\u30B9\u30C6\u30E0\u306B\u3088\u308B\u30EA\u30D4\u30C9A\u306E\u611F\u77E5\u306F\u3001\u30B0\u30E9\u30E0\u9670\u6027\u83CC\u306E\u611F\u67D3\u306B\u5BFE\u3059\u308B\u514D\u75AB\u5FDC\u7B54\u306E\u958B\u59CB\u306B\u91CD\u8981\u306A\u5F79\u5272\u3092\u679C\u305F\u3057\u3066\u3044\u308B\u3002LIPID MAPS\u306B\u3088\u308B\u5206\u985E\u3067\u7CD6\u8102\u8CEA\uFF08Saccharolipids\uFF09\u306B\u5206\u985E\u3055\u308C\u3066\u3044\u308B\u3002"@ja . . . . "\u8102\u8D28A\uFF08\u82F1\u8A9E\uFF1Alipid A\uFF09\u4E3A\u4E00\u79CD\u7CD6\u78F7\u8102\uFF0C\u7531D-\u6C28\u57FA\u8461\u8404\u7CD6\u53CC\u7CD6\u7EC4\u6210\u7684\u57FA\u672C\u9AA8\u67B6\uFF0C\u4E0D\u540C\u7EC6\u83CC\u9AA8\u67B6\u4E00\u81F4\u3002\u5177\u6709\u5185\u6BD2\u7D20\u6BD2\u6027\u4E0E\u751F\u7269\u5B66\u6D3B\u6027\u6210\u5206\uFF0C\u65E0\u79CD\u5C5E\u7279\u5F02\u6027\u3002"@zh . . . . .