. "44183"^^ . "MAPK14 (\u0430\u043D\u0433\u043B. Mitogen-activated protein kinase 14) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 6-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 360 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 41 293. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043DW: \u0422\u0440\u0438\u043F\u0442\u043E\u0444\u0430\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D \u041A\u043E\u0434\u043E\u0432\u0430\u043D\u0438\u0439 \u0433\u0435\u043D\u043E\u043C \u0431\u0456\u043B\u043E\u043A \u0437\u0430 \u0444\u0443\u043D\u043A\u0446\u0456\u044F\u043C\u0438 \u043D\u0430\u043B\u0435\u0436\u0438\u0442\u044C \u0434\u043E \u0442\u0440\u0430\u043D\u0441\u0444\u0435\u0440\u0430\u0437, \u043A\u0456\u043D\u0430\u0437, \u0441\u0435\u0440\u0438\u043D/\u0442\u0440\u0435\u043E\u043D\u0456\u043D\u043E\u0432\u0438\u0445 \u043F\u0440\u043E\u0442\u0435\u0457\u043D\u043A\u0456\u043D\u0430\u0437, \u0444\u043E\u0441\u0444\u043E\u043F\u0440\u043E\u0442\u0435\u0457\u043D\u0456\u0432. \u0417\u0430\u0434\u0456\u044F\u043D\u0438\u0439 \u0443 \u0442\u0430\u043A\u0438\u0445 \u0431\u0456\u043E\u043B\u043E\u0433\u0456\u0447\u043D\u0438\u0445 \u043F\u0440\u043E\u0446\u0435\u0441\u0430\u0445, \u044F\u043A \u0430\u043F\u043E\u043F\u0442\u043E\u0437, \u0432\u0456\u0434\u043F\u043E\u0432\u0456\u0434\u044C \u043D\u0430 \u0441\u0442\u0440\u0435\u0441, \u0442\u0440\u0430\u043D\u0441\u043A\u0440\u0438\u043F\u0446\u0456\u044F, \u0440\u0435\u0433\u0443\u043B\u044F\u0446\u0456\u044F \u0442\u0440\u0430\u043D\u0441\u043A\u0440\u0438\u043F\u0446\u0456\u0457, \u0430\u0446\u0435\u0442\u0438\u043B\u044E\u0432\u0430\u043D\u043D\u044F, \u0430\u043B\u044C\u0442\u0435\u0440\u043D\u0430\u0442\u0438\u0432\u043D\u0438\u0439 \u0441\u043F\u043B\u0430\u0439\u0441\u0438\u043D\u0433. \u0411\u0456\u043B\u043E\u043A \u043C\u0430\u0454 \u0441\u0430\u0439\u0442 \u0434\u043B\u044F \u0437\u0432'\u044F\u0437\u0443\u0432\u0430\u043D\u043D\u044F \u0437 \u0410\u0422\u0424, \u043D\u0443\u043A\u043B\u0435\u043E\u0442\u0438\u0434\u0430\u043C\u0438. \u041B\u043E\u043A\u0430\u043B\u0456\u0437\u043E\u0432\u0430\u043D\u0438\u0439 \u0443 \u0446\u0438\u0442\u043E\u043F\u043B\u0430\u0437\u043C\u0456, \u044F\u0434\u0440\u0456."@uk . . . . . . . . . . . "La MAP quinasa 14 (MAPK14) es una enzima codificada en humanos por el gen mapk14.\u200B La MAPK14 pertenece a la familia de las . Las MAP quinasas act\u00FAan como punto de integraci\u00F3n de m\u00FAltiples se\u00F1ales bioqu\u00EDmicas, y est\u00E1n implicadas en una amplia variedad de procesos celulares tales como proliferaci\u00F3n celular, diferenciaci\u00F3n celular, regulaci\u00F3n de la transcripci\u00F3n y desarrollo. La MAPK14 es activada por diversos est\u00EDmulos ambientales relacionados con el estr\u00E9s y por citoquinas proinflamatorias. Dicha activaci\u00F3n requiere la fosforilaci\u00F3n llevada a cabo por MAP quinasa quinasas (MKKs), o bien su propia autofosforilaci\u00F3n llevada a cabo por la interacci\u00F3n del complejo MAP3K7IP1/TAB1 con MAPK14. Los sustratos de esta quinasa incluyen diversas prote\u00EDnas o factores de transcripci\u00F3n como ATF2, MEF2C, MAX, el regulador del ciclo celular CDC25B y el supresor tumoral p53, lo que sugiere un papel de esta quinasa en regulaci\u00F3n del ciclo celular y la transcripci\u00F3n, as\u00ED como en respuesta a estr\u00E9s genot\u00F3xico. Se han descrito cuatro variantes transcripcionales de este gen, que codifican diversas isoformas de la quinasa.\u200B"@es . . . . . . . . . . . . "1116935632"^^ . . "MAPK14"@es . . "P698|from=Q28603117"@en . . . . . . "P1476|from=Q28603117"@en . . . . . . . "2021-04-15"^^ . . . . . . "13570754"^^ . . . "P577|from=Q28603117"@en . . . . . . . . . . . . . . . . . "MAPK14"@uk . . . . "MAPK14"@en . . "P932|from=Q28603117"@en . . . . . "P2093|from=Q28603117"@en . "La MAP quinasa 14 (MAPK14) es una enzima codificada en humanos por el gen mapk14.\u200B La MAPK14 pertenece a la familia de las . Las MAP quinasas act\u00FAan como punto de integraci\u00F3n de m\u00FAltiples se\u00F1ales bioqu\u00EDmicas, y est\u00E1n implicadas en una amplia variedad de procesos celulares tales como proliferaci\u00F3n celular, diferenciaci\u00F3n celular, regulaci\u00F3n de la transcripci\u00F3n y desarrollo. La MAPK14 es activada por diversos est\u00EDmulos ambientales relacionados con el estr\u00E9s y por citoquinas proinflamatorias. Dicha activaci\u00F3n requiere la fosforilaci\u00F3n llevada a cabo por MAP quinasa quinasas (MKKs), o bien su propia autofosforilaci\u00F3n llevada a cabo por la interacci\u00F3n del complejo MAP3K7IP1/TAB1 con MAPK14. Los sustratos de esta quinasa incluyen diversas prote\u00EDnas o factores de transcripci\u00F3n como ATF2, MEF2C, M"@es . . . . . . . . . . . . . . "2015"^^ . . . "Mitogen-activated protein kinase 14, also called p38-\u03B1, is an enzyme that in humans is encoded by the MAPK14 gene. MAPK14 encodes p38\u03B1 mitogen-activated protein kinase (MAPK) which is the prototypic member of the p38 MAPK family. p38 MAPKs are also known as stress-activated serine/threonine-specific kinases (SAPKs). In addition to MAPK14 for p38\u03B1 MAPK, the p38 MAPK family has three additional members, including MAPK11, MAPK12 and MAPK13 which encodes p38\u03B2 MAPK, p38\u03B3 MAPK and p38\u03B4 MAPK isoforms, respectively. p38\u03B1 MAPK was originally identified as a tyrosine phosphorylated protein detected in activated immune cell macrophages with an essential role in inflammatory cytokine induction, such as Tumor Necrotic Factor \u03B1 (TNF\u03B1). However, p38\u03B1 MAPK mediated kinase activity has been implicated in many tissues beyond immune systems. p38\u03B1 MAPK is mainly activated through MAPK kinase kinase cascades and exerts its biological function via downstream substrate phosphorylation. p38\u03B1 MAPK is implicated in diverse cellular functions, from gene expression to programmed cell death through a network of signaling molecules and transcription factors. Pharmacological and genetic inhibition of p38\u03B1 MAPK not only revealed its biological significance in physiological function but also the potential of targeting p38\u03B1 MAPK in human disease such as immune disorders and heart failure."@en . "Mitogen-activated protein kinase 14, also called p38-\u03B1, is an enzyme that in humans is encoded by the MAPK14 gene. MAPK14 encodes p38\u03B1 mitogen-activated protein kinase (MAPK) which is the prototypic member of the p38 MAPK family. p38 MAPKs are also known as stress-activated serine/threonine-specific kinases (SAPKs). In addition to MAPK14 for p38\u03B1 MAPK, the p38 MAPK family has three additional members, including MAPK11, MAPK12 and MAPK13 which encodes p38\u03B2 MAPK, p38\u03B3 MAPK and p38\u03B4 MAPK isoforms, respectively. p38\u03B1 MAPK was originally identified as a tyrosine phosphorylated protein detected in activated immune cell macrophages with an essential role in inflammatory cytokine induction, such as Tumor Necrotic Factor \u03B1 (TNF\u03B1). However, p38\u03B1 MAPK mediated kinase activity has been implicated in m"@en . . . . . "P478|from=Q28603117"@en . . . . . . . "MAPK14 (\u0430\u043D\u0433\u043B. Mitogen-activated protein kinase 14) \u2013 \u0431\u0456\u043B\u043E\u043A, \u044F\u043A\u0438\u0439 \u043A\u043E\u0434\u0443\u0454\u0442\u044C\u0441\u044F \u043E\u0434\u043D\u043E\u0439\u043C\u0435\u043D\u043D\u0438\u043C \u0433\u0435\u043D\u043E\u043C, \u0440\u043E\u0437\u0442\u0430\u0448\u043E\u0432\u0430\u043D\u0438\u043C \u0443 \u043B\u044E\u0434\u0435\u0439 \u043D\u0430 \u043A\u043E\u0440\u043E\u0442\u043A\u043E\u043C\u0443 \u043F\u043B\u0435\u0447\u0456 6-\u0457 \u0445\u0440\u043E\u043C\u043E\u0441\u043E\u043C\u0438. \u0414\u043E\u0432\u0436\u0438\u043D\u0430 \u043F\u043E\u043B\u0456\u043F\u0435\u043F\u0442\u0438\u0434\u043D\u043E\u0433\u043E \u043B\u0430\u043D\u0446\u044E\u0433\u0430 \u0431\u0456\u043B\u043A\u0430 \u0441\u0442\u0430\u043D\u043E\u0432\u0438\u0442\u044C 360 \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442, \u0430 \u043C\u043E\u043B\u0435\u043A\u0443\u043B\u044F\u0440\u043D\u0430 \u043C\u0430\u0441\u0430 \u2014 41 293. \u041F\u043E\u0441\u043B\u0456\u0434\u043E\u0432\u043D\u0456\u0441\u0442\u044C \u0430\u043C\u0456\u043D\u043E\u043A\u0438\u0441\u043B\u043E\u0442 A: \u0410\u043B\u0430\u043D\u0456\u043DC: \u0426\u0438\u0441\u0442\u0435\u0457\u043DD: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430E: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043D\u043E\u0432\u0430 \u043A\u0438\u0441\u043B\u043E\u0442\u0430F: \u0424\u0435\u043D\u0456\u043B\u0430\u043B\u0430\u043D\u0456\u043DG: \u0413\u043B\u0456\u0446\u0438\u043DH: \u0413\u0456\u0441\u0442\u0438\u0434\u0438\u043DI: \u0406\u0437\u043E\u043B\u0435\u0439\u0446\u0438\u043DK: \u041B\u0456\u0437\u0438\u043DL: \u041B\u0435\u0439\u0446\u0438\u043DM: \u041C\u0435\u0442\u0456\u043E\u043D\u0456\u043DN: \u0410\u0441\u043F\u0430\u0440\u0430\u0433\u0456\u043DP: \u041F\u0440\u043E\u043B\u0456\u043DQ: \u0413\u043B\u0443\u0442\u0430\u043C\u0456\u043DR: \u0410\u0440\u0433\u0456\u043D\u0456\u043DS: \u0421\u0435\u0440\u0438\u043DT: \u0422\u0440\u0435\u043E\u043D\u0456\u043DV: \u0412\u0430\u043B\u0456\u043DW: \u0422\u0440\u0438\u043F\u0442\u043E\u0444\u0430\u043D Y: \u0422\u0438\u0440\u043E\u0437\u0438\u043D"@uk . . . "P304|from=Q28603117"@en . . . . . "P433|from=Q28603117"@en . . . . . "P356|from=Q28603117"@en . . .