. "Nalbuphin ist ein Arzneistoff aus der Gruppe der Schmerzmittel vom Opioid-Typ. Er wirkt agonistisch an den \u03BA-Opioidrezeptoren und partiell antagonistisch an den \u00B5-Opioidrezeptoren. Die Vorteile des Partialantagonisten liegen darin, dass eine opioidbedingte Atemdepression, z. B. postoperativ nach dem Einsatz von Fentanyl w\u00E4hrend der Narkose, aufgehoben werden kann bei gleichzeitiger Fortf\u00FChrung der Schmerzbehandlung, da Nalbuphin selbst analgetisch wirkt. Die analgetische Potenz verglichen mit Morphin liegt bei 0,5\u20130,8. Es ist dem Pentazocin \u00E4hnlich, steigert jedoch den Blutdruck und die Herzfrequenz nicht.Bei opiatabh\u00E4ngigen Patienten kann der Einsatz von Nalbuphin allerdings sofort nach der Injektion ein Entzugssyndrom hervorrufen. Nalbuphin wird als Hydrochlorid in Injektionsl\u00F6sungen eingesetzt. Die Wirkung tritt rasch nach zwei bis drei Minuten ein. Die Halbwertszeit betr\u00E4gt circa drei Stunden, die Wirkdauer bis zu sechs Stunden. Die gleichzeitige Gabe zu einer Behandlung mit \u03BC-agonistischen Opioiden wie etwa Morphin oder Fentanyl ist kontraindiziert."@de . . "verified"@en . "895"^^ . . . "27"^^ . "a682668"@en . . . . . . . . . . . "1663"^^ . "21"^^ . "Skeletal formula"@en . . "900.0"^^ . . . . . . . . "4470813"^^ . . . "Ball-and-stick model of nalbuphine"@en . "Nalbufina"@pt . . "La nalbuphine est un antalgique opiac\u00E9 fort utilis\u00E9 pour traiter les douleurs intenses ou rebelles aux autres antalgiques. Elle est susceptible d'entra\u00EEner une d\u00E9pendance. Elle agit en bloquant les influx nerveux v\u00E9hiculant la douleur."@fr . . "20594-83-6" . . "225"^^ . . "\u7EB3\u5E03\u5561\u662F\u4E00\u79CD\u963F\u7247\u7C7B\u53D7\u4F53\u7684\u9547\u9759\u5242\u578B\u7CBE\u795E\u836F\u7269\uFF0C\u5176\u9547\u9759\u6548\u679C\u7C7B\u4F3C\u5417\u5561\uFF0C\u6709\u547C\u5438\u6291\u5236\u4F5C\u7528\u4F46\u4E0D\u660E\u663E\u3002\u540C\u65F6\u5176\u6291\u5236\u6709\u5C01\u9876\u6548\u5E94\uFF0C\u65E0\u5FC3\u8840\u7BA1\u526F\u53CD\u5E94\uFF0C\u4E34\u5E8A\u4E0A\u4E00\u822C\u7528\u4E8E\u624B\u672F\u540E\u9547\u75DB\u3002"@zh . "7454" . . . "AF02"@en . . . . . . . . . . . . "O[C@@H]4[C@@H]5Oc1c2cC[C@H]3NCC6CCC6"@en . "NETZHAKZCGBWSS-CEDHKZHLSA-N"@en . . . . . . . "250"^^ . . . "20594"^^ . "Schedule IV"@en . . "Nalbufin"@cs . "Nalbuphin ist ein Arzneistoff aus der Gruppe der Schmerzmittel vom Opioid-Typ. Er wirkt agonistisch an den \u03BA-Opioidrezeptoren und partiell antagonistisch an den \u00B5-Opioidrezeptoren. Die Vorteile des Partialantagonisten liegen darin, dass eine opioidbedingte Atemdepression, z. B. postoperativ nach dem Einsatz von Fentanyl w\u00E4hrend der Narkose, aufgehoben werden kann bei gleichzeitiger Fortf\u00FChrung der Schmerzbehandlung, da Nalbuphin selbst analgetisch wirkt. Die analgetische Potenz verglichen mit Morphin liegt bei 0,5\u20130,8. Es ist dem Pentazocin \u00E4hnlich, steigert jedoch den Blutdruck und die Herzfrequenz nicht.Bei opiatabh\u00E4ngigen Patienten kann der Einsatz von Nalbuphin allerdings sofort nach der Injektion ein Entzugssyndrom hervorrufen."@de . . . . . . "Liver"@en . . . . . . . . . . . . . . . . . . "a682668" . . . "\u041D\u0430\u043B\u0431\u0443\u0444\u0438\u043D"@ru . "\u7EB3\u5E03\u5561\u662F\u4E00\u79CD\u963F\u7247\u7C7B\u53D7\u4F53\u7684\u9547\u9759\u5242\u578B\u7CBE\u795E\u836F\u7269\uFF0C\u5176\u9547\u9759\u6548\u679C\u7C7B\u4F3C\u5417\u5561\uFF0C\u6709\u547C\u5438\u6291\u5236\u4F5C\u7528\u4F46\u4E0D\u660E\u663E\u3002\u540C\u65F6\u5176\u6291\u5236\u6709\u5C01\u9876\u6548\u5E94\uFF0C\u65E0\u5FC3\u8840\u7BA1\u526F\u53CD\u5E94\uFF0C\u4E34\u5E8A\u4E0A\u4E00\u822C\u7528\u4E8E\u624B\u672F\u540E\u9547\u75DB\u3002"@zh . . . "B"@en . . "L2T84IQI2K" . "verified"@en . "\u0646\u0627\u0644\u0628\u0648\u0641\u064A\u0646 Nalbuphine \u0623\u0648 Nubain \u0647\u0648 \u0645\u0633\u0643\u0646 \u0623\u0641\u064A\u0648\u0646\u064A \u0646\u0635\u0641 \u0635\u0646\u0639\u064A. \u064A\u0643\u0648\u0646 \u0641\u0639\u0627\u0644 \u0641\u064A \u0627\u0644\u0646\u0633\u0627\u0621 \u0623\u0643\u062B\u0631 \u0645\u0646 \u0627\u0644\u0631\u062C\u0627\u0644\u060C \u0628\u0644 \u062D\u062A\u0649 \u064A\u0645\u0643\u0646 \u0623\u0646 \u064A\u0632\u064A\u062F \u0627\u0644\u0623\u0644\u0645 \u0644\u062F\u0649 \u0627\u0644\u0631\u062C\u0627\u0644. \u064A\u064F\u0633\u062A\u064E\u0639\u0645\u064E\u0644 \u0644\u0644\u062A\u0646\u0648\u064A\u0645 \u062E\u0644\u0627\u0644 \u0627\u0644\u0639\u0645\u0644\u064A\u0627\u062A \u0627\u0644\u062C\u0631\u0627\u062D\u064A\u0629 \u0643\u0645\u0627 \u064A\u0633\u062A\u062E\u062F\u0645 \u0644\u062A\u062E\u0641\u064A\u0641 \u0634\u062F\u064E\u0651\u0629 \u0627\u0644\u0622\u0644\u0627\u0645.. \u064A\u0648\u062C\u062F \u0639\u0644\u0649 \u0634\u0643\u0644 \u0645\u0644\u062D\u064A\u0646 \u0628\u0627\u0631\u0627\u0628\u064A\u0646 \u0623\u0648 \u0633\u0644\u0641\u064A\u062A."@ar . "Nalbufina \u00E9 um f\u00E1rmaco utilizado como analg\u00E9sico opi\u00F3ide, utilizado no tratamento da dor. Nalbufina \u00E9 um analg\u00E9sico narc\u00F3tico agonista-antagonista. Relacionado quimicamente com naloxona, tem pot\u00EAncia analg\u00E9sica semelhante a morfina. Atua principalmente nos receptores kappa como agonista total e agonista parcial dos receptores mu. Produz depressao respirat\u00F3ria, por\u00E9m diferente da morfina e outros opi\u00F3ides h\u00E1 efeito teto. Quando administrada concomitantemente com analg\u00E9sicos opi\u00F3ides ou agonistas pode reverter parcialmente ou bloquear a depressao respirat\u00F3ria narc\u00F3tico-induzida. utilizada em casos de intoxica\u00E7\u00E3o por hipnoanalg\u00E9sicos."@pt . "Nalbufina \u00E9 um f\u00E1rmaco utilizado como analg\u00E9sico opi\u00F3ide, utilizado no tratamento da dor. Nalbufina \u00E9 um analg\u00E9sico narc\u00F3tico agonista-antagonista. Relacionado quimicamente com naloxona, tem pot\u00EAncia analg\u00E9sica semelhante a morfina. Atua principalmente nos receptores kappa como agonista total e agonista parcial dos receptores mu. Produz depressao respirat\u00F3ria, por\u00E9m diferente da morfina e outros opi\u00F3ides h\u00E1 efeito teto. Quando administrada concomitantemente com analg\u00E9sicos opi\u00F3ides ou agonistas pode reverter parcialmente ou bloquear a depressao respirat\u00F3ria narc\u00F3tico-induzida."@pt . . . . . . "1112575781"^^ . "\u7EB3\u5E03\u5561"@zh . . "1800.0"^^ . . . . . "S4"@en . . . . . . . "Nalbufin je opioidn\u00ED analgetikum pou\u017E\u00EDvan\u00E9 pro l\u00E9\u010Dbu bolesti. Pod\u00E1v\u00E1 se injek\u010Dn\u011B do \u017E\u00EDly, svalu nebo tuku. Mezi vedlej\u0161\u00ED \u00FA\u010Dinky nalbufinu pat\u0159\u00ED sedace, pocen\u00ED, nevolnost, zvracen\u00ED, z\u00E1vra\u0165, sucho v \u00FAstech a bolest hlavy. Na rozd\u00EDl od v\u011Bt\u0161iny ostatn\u00EDch opioid\u016F vyvol\u00E1v\u00E1 Nalbufin jen slabou euforii a od ur\u010Dit\u00E9 d\u00E1vky ji\u017E d\u00E1le nezesiluje \u00FAtlum d\u00FDchac\u00EDho centra. Je zde tak\u00E9 t\u00E9m\u011B\u0159 nulov\u00E1 incidence dysforie, disociativn\u00EDch stav\u016F \u010Di halucinac\u00ED, bere-li se l\u00E9k v obvykl\u00FDch terapeutick\u00FDch d\u00E1vk\u00E1ch. Nalbufin je sm\u00ED\u0161en\u00FD agonista-antagonista opioidov\u00FDch receptor\u016F."@cs . . . . "Nubain, Nalpain, Nalbuphin, others"@en . . . . . . "Nalbuphine"@en . . . . . . "\u2022 : 81% , 83%"@en . "\u2022 Oral: 11% , >44%"@en . "-3"^^ . . . "1"^^ . . "895" . . . "2395985"^^ . . "\u041D\u0430\u043B\u0431\u0443\u0444\u0438\u043D (Nalbuphine) \u2014 \u043E\u043F\u0438\u043E\u0438\u0434\u043D\u044B\u0439 \u0430\u043D\u0430\u043B\u044C\u0433\u0435\u0442\u0438\u043A."@ru . . . . . . . . "Nalbuphine, sold under the brand names Nubain among others, is an opioid analgesic which is used in the treatment of pain. It is given by injection into a vein, muscle, or fat. Side effects of nalbuphine include sedation, sweatiness, clamminess, nausea, vomiting, dizziness, vertigo, dry mouth, and headache. Unlike other opioids, it has little to no capacity for euphoria or respiratory depression. It also has little to no incidence of dysphoria, dissociation, hallucinations, and related side effects at typical therapeutic doses. Nalbuphine is a mixed agonist/antagonist opioid modulator. Specifically, it acts as a moderate-efficacy partial agonist or antagonist of the \u03BC-opioid receptor (MOR) and as a high-efficacy partial agonist of the \u03BA-opioid receptor (KOR), whereas it has relatively low "@en . "La nalbuphine est un antalgique opiac\u00E9 fort utilis\u00E9 pour traiter les douleurs intenses ou rebelles aux autres antalgiques. Elle est susceptible d'entra\u00EEner une d\u00E9pendance. Elle agit en bloquant les influx nerveux v\u00E9hiculant la douleur."@fr . . . . . . "4"^^ . . . . . "Nalbufin je opioidn\u00ED analgetikum pou\u017E\u00EDvan\u00E9 pro l\u00E9\u010Dbu bolesti. Pod\u00E1v\u00E1 se injek\u010Dn\u011B do \u017E\u00EDly, svalu nebo tuku. Mezi vedlej\u0161\u00ED \u00FA\u010Dinky nalbufinu pat\u0159\u00ED sedace, pocen\u00ED, nevolnost, zvracen\u00ED, z\u00E1vra\u0165, sucho v \u00FAstech a bolest hlavy. Na rozd\u00EDl od v\u011Bt\u0161iny ostatn\u00EDch opioid\u016F vyvol\u00E1v\u00E1 Nalbufin jen slabou euforii a od ur\u010Dit\u00E9 d\u00E1vky ji\u017E d\u00E1le nezesiluje \u00FAtlum d\u00FDchac\u00EDho centra. Je zde tak\u00E9 t\u00E9m\u011B\u0159 nulov\u00E1 incidence dysforie, disociativn\u00EDch stav\u016F \u010Di halucinac\u00ED, bere-li se l\u00E9k v obvykl\u00FDch terapeutick\u00FDch d\u00E1vk\u00E1ch. Nalbufin je sm\u00ED\u0161en\u00FD agonista-antagonista opioidov\u00FDch receptor\u016F. Nalbufin byl objeven roku 1965 a v roce 1979 byl ve Spojen\u00FDch st\u00E1tech americk\u00FDch schv\u00E1len \u00DA\u0159adem pro kontrolu potravin a l\u00E9\u010Div."@cs . . . "5311304"^^ . . . "7454"^^ . . "459830736"^^ . . . "Nalbuphine molecule ball.png"@en . . . . . "\u0646\u0627\u0644\u0628\u0648\u0641\u064A\u0646"@ar . . . "\u2022 : 76% , 79%"@en . . . "1"^^ . . . . "EN-2234A; N-Cyclobutylmethyl-14-hydroxydihydronormorphine; 17-Cyclobutylmethyl-4,5\u03B1-epoxymorphinan-3,6\u03B1,14-triol; N-Cyclobutylmethyl-4,5\u03B1-epoxy-3,6\u03B1,14-morphinantriol"@en . "Rx only Schedule IV in some states"@en . . "18000.0"^^ . "\u041D\u0430\u043B\u0431\u0443\u0444\u0456\u043D (\u0430\u043D\u0433\u043B. Nalbuphine, \u043B\u0430\u0442. Nalbuphinum) \u2014 \u0441\u0438\u043D\u0442\u0435\u0442\u0438\u0447\u043D\u0438\u0439 \u043B\u0456\u043A\u0430\u0440\u0441\u044C\u043A\u0438\u0439 \u0437\u0430\u0441\u0456\u0431, \u0449\u043E \u043D\u0430\u043B\u0435\u0436\u0438\u0442\u044C \u0434\u043E \u0433\u0440\u0443\u043F\u0438 \u043E\u043F\u0456\u043E\u0457\u0434\u043D\u0438\u0445 \u0430\u043D\u0430\u043B\u044C\u0433\u0435\u0442\u0438\u043A\u0456\u0432 \u0456 \u0454 \u043F\u043E\u0445\u0456\u0434\u043D\u0438\u043C \u0444\u0435\u043D\u0430\u043D\u0442\u0440\u0435\u043D\u0443. \u041D\u0430\u043B\u0431\u0443\u0444\u0456\u043D \u0437\u0430\u0441\u0442\u043E\u0441\u043E\u0432\u0443\u0454\u0442\u044C\u0441\u044F \u043F\u0435\u0440\u0435\u0432\u0430\u0436\u043D\u043E \u043F\u0430\u0440\u0435\u043D\u0442\u0435\u0440\u0430\u043B\u044C\u043D\u043E, \u044F\u043A \u0432\u043D\u0443\u0442\u0440\u0456\u0448\u043D\u044C\u043E\u0432\u0435\u043D\u043D\u043E, \u0442\u0430\u043A \u0456 \u0432\u043D\u0443\u0442\u0440\u0456\u0448\u043D\u044C\u043E\u043C'\u044F\u0437\u043E\u0432\u043E \u0456 \u043F\u0456\u0434\u0448\u043A\u0456\u0440\u043D\u043E, \u0432\u043A\u0440\u0430\u0439 \u0440\u0456\u0434\u043A\u043E \u043F\u0440\u0435\u043F\u0430\u0440\u0430\u0442 \u0437\u0430\u0441\u0442\u043E\u0441\u043E\u0432\u0443\u0454\u0442\u044C\u0441\u044F \u043F\u0435\u0440\u043E\u0440\u0430\u043B\u044C\u043D\u043E. \u041D\u0430\u043B\u0431\u0443\u0444\u0456\u043D \u0443\u043F\u0435\u0440\u0448\u0435 \u0437\u0430\u043F\u0430\u0442\u0435\u043D\u0442\u043E\u0432\u0430\u043D\u043E \u0443 1963 \u0440\u043E\u0446\u0456 \u0432 \u0421\u0428\u0410 \u0456 \u0441\u0445\u0432\u0430\u043B\u0435\u043D\u043E \u0434\u043B\u044F \u043A\u043B\u0456\u043D\u0456\u0447\u043D\u043E\u0433\u043E \u0437\u0430\u0441\u0442\u043E\u0441\u0443\u0432\u0430\u043D\u043D\u044F \u0432 1979 \u0440\u043E\u0446\u0456."@uk . "25615"^^ . . "Nalbuphine, sold under the brand names Nubain among others, is an opioid analgesic which is used in the treatment of pain. It is given by injection into a vein, muscle, or fat. Side effects of nalbuphine include sedation, sweatiness, clamminess, nausea, vomiting, dizziness, vertigo, dry mouth, and headache. Unlike other opioids, it has little to no capacity for euphoria or respiratory depression. It also has little to no incidence of dysphoria, dissociation, hallucinations, and related side effects at typical therapeutic doses. Nalbuphine is a mixed agonist/antagonist opioid modulator. Specifically, it acts as a moderate-efficacy partial agonist or antagonist of the \u03BC-opioid receptor (MOR) and as a high-efficacy partial agonist of the \u03BA-opioid receptor (KOR), whereas it has relatively low affinity for the \u03B4-opioid receptor (DOR) and sigma receptors. Nalbuphine was patented in 1963 and was introduced for medical use in the United States in 1979. It is marketed in many countries throughout the world."@en . . . . . "L2T84IQI2K"@en . . . . "Nalbuphin"@de . . . . . "21600.0"^^ . . . . "Nubain, Nalpain, Nalbuphin, others"@en . . . . . "\u041D\u0430\u043B\u0431\u0443\u0444\u0438\u043D (Nalbuphine) \u2014 \u043E\u043F\u0438\u043E\u0438\u0434\u043D\u044B\u0439 \u0430\u043D\u0430\u043B\u044C\u0433\u0435\u0442\u0438\u043A."@ru . . . "Glucuronide conjugates , others"@en . "3600.0"^^ . "-21600.0"^^ . . . . . . . . . . "Federally Uncontrolled , except in KY, C-IV"@en . . "DB00844" . "DB00844"@en . . . "-180.0"^^ . . "N02"@en . . . . . . "\u041D\u0430\u043B\u0431\u0443\u0444\u0456\u043D"@uk . . . "5311304" . . . . . "Nalbuphine"@fr . . "50.0"^^ . "\u0646\u0627\u0644\u0628\u0648\u0641\u064A\u0646 Nalbuphine \u0623\u0648 Nubain \u0647\u0648 \u0645\u0633\u0643\u0646 \u0623\u0641\u064A\u0648\u0646\u064A \u0646\u0635\u0641 \u0635\u0646\u0639\u064A. \u064A\u0643\u0648\u0646 \u0641\u0639\u0627\u0644 \u0641\u064A \u0627\u0644\u0646\u0633\u0627\u0621 \u0623\u0643\u062B\u0631 \u0645\u0646 \u0627\u0644\u0631\u062C\u0627\u0644\u060C \u0628\u0644 \u062D\u062A\u0649 \u064A\u0645\u0643\u0646 \u0623\u0646 \u064A\u0632\u064A\u062F \u0627\u0644\u0623\u0644\u0645 \u0644\u062F\u0649 \u0627\u0644\u0631\u062C\u0627\u0644. \u064A\u064F\u0633\u062A\u064E\u0639\u0645\u064E\u0644 \u0644\u0644\u062A\u0646\u0648\u064A\u0645 \u062E\u0644\u0627\u0644 \u0627\u0644\u0639\u0645\u0644\u064A\u0627\u062A \u0627\u0644\u062C\u0631\u0627\u062D\u064A\u0629 \u0643\u0645\u0627 \u064A\u0633\u062A\u062E\u062F\u0645 \u0644\u062A\u062E\u0641\u064A\u0641 \u0634\u062F\u064E\u0651\u0629 \u0627\u0644\u0622\u0644\u0627\u0645.. \u064A\u0648\u062C\u062F \u0639\u0644\u0649 \u0634\u0643\u0644 \u0645\u0644\u062D\u064A\u0646 \u0628\u0627\u0631\u0627\u0628\u064A\u0646 \u0623\u0648 \u0633\u0644\u0641\u064A\u062A."@ar . . . "\u041D\u0430\u043B\u0431\u0443\u0444\u0456\u043D (\u0430\u043D\u0433\u043B. Nalbuphine, \u043B\u0430\u0442. 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