. . . . "Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus. It consists of two parts, a labile chromophore (the non-protein molecular entity shown at right) and a 113 amino acid protein to which the chromophore is tightly and non-covalently bound with high affinity (Kd ~ 10\u221210 M). The non-protein component is a very potent DNA-damaging agent; However it is extremely unstable and the role of the protein is to protect it and release it to the target DNA. Opening of the epoxide under reductive conditions present in cells creates favorable conditions for a Masamune-Bergman cyclization, leading to formation of benzyne, followed by DNA strand cleavage. Another important member of the chromoprotein group of natural products is "@en . . . . "(-6-{[-4,5-Dihydroxy-6-methyl-3-tetrahydro-2H-pyran-2-yl]oxy}-1a--2,3,8,9-tetradehydro-1a,5,6,9a-tetrahydrocyclopenta[5,6]cyclonona[1,2-b]oxiren-5-yl 2-hydroxy-7-methoxy-5-methyl-1-naphthoate)"@en . . "La zinostatina (nota anche con il nome di neocarzinostatina) \u00E8 un antibiotico,un alchene appartenente alla famiglia delle enediyne (ovvero composti con tripli legami per ogni lato di un doppio legame), dotato di attivit\u00E0 antitumorale. La molecola \u00E8 un polipeptide, pi\u00F9 precisamente una apoproteina, consistente di due parti, una proteica del peso molecolare di 10.700, contenente 109 residui aminoacidici di 18 tipi differenti, e di un cromoforo, labile, di natura non proteica, con struttura biciclica, responsabile della attivit\u00E0 biologica della sostanza. Nella molecola sono presenti due ponti disolfuro tra la cisteina. L'integrit\u00E0 della struttura, ivi compreso il collegamento trasversale dei ponti disolfuro, \u00E8 essenziale per l'espletamento dell'attivit\u00E0 biologica."@it . . "Neocarzinostatin chromophore"@en . . . "Space-filling model of the neocarzinostatin molecule"@en . . . "Zinostatina"@it . . . . "Structural formula of neocarzinostatin"@en . . . . "Neocarzinostatin 3D spacefill.png"@en . . . . "changed"@en . "Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus. It consists of two parts, a labile chromophore (the non-protein molecular entity shown at right) and a 113 amino acid protein to which the chromophore is tightly and non-covalently bound with high affinity (Kd ~ 10\u221210 M). The non-protein component is a very potent DNA-damaging agent; However it is extremely unstable and the role of the protein is to protect it and release it to the target DNA. Opening of the epoxide under reductive conditions present in cells creates favorable conditions for a Masamune-Bergman cyclization, leading to formation of benzyne, followed by DNA strand cleavage. Another important member of the chromoprotein group of natural products is kedarcidin. As a medicine it is among the most potent, and in Japan only it has been used against liver cancer clinically."@en . "\u30CD\u30AA\u30AB\u30EB\u30B8\u30CE\u30B9\u30BF\u30C1\u30F3"@ja . . . . "(1aS,5R,6R,6aE)-6-{[(2R,3R,4R,5R,6R)-4,5-Dihydroxy-6-methyl-3-(methylamino)tetrahydro-2H-pyran-2-yl]oxy}-1a-(2-oxo-1,3-dioxolan-4-yl)-2,3,8,9-tetradehydro-1a,5,6,9a-tetrahydrocyclopenta[5,6]cyclonona[1,2-b]oxiren-5-yl 2-hydroxy-7-methoxy-5-methyl-1-naphthoate)"@en . . . . . . . . . . . . . . "Neocarzinostatin chromophore"@en . . . . "7692"^^ . . . "Zinostatin (auch: Neocarzinostatin) ist ein Arzneistoff aus der Gruppe der Endiin-Antibiotika mit antineoplastischer Wirkung. Verantwortlich f\u00FCr die Antitumor-Wirkung ist ein chromophorer Teil, der nicht-kovalent an ein aus 113 Aminos\u00E4uren bestehendes Apoprotein gebunden ist. Das Chromophor ist ohne die Bindung an das Peptid chemisch instabil. Das Peptid besteht aus einer einzigen Kette. Zinostatin wird aus Kulturen von Streptomyces carcinostaticus var. F-41 gewonnen. Das Neocarzinostatin-Chromophor verursacht an der DNA Strangbr\u00FCche, bevorzugt an der Desoxyribose des Thymins. Das Konjugat aus Zinostatin mit Styrol-Maleins\u00E4ure-Copolymer wurde bis 2009 in Japan zur Behandlung des Leberzellkarzinoms verwendet."@de . "Zinostatin"@de . . . . . . . . . "Neocarzinostatin"@en . . . . . . . . . . "441386715"^^ . . . . . . . "7031301"^^ . . . "changed"@en . . . "La zinostatina (nota anche con il nome di neocarzinostatina) \u00E8 un antibiotico,un alchene appartenente alla famiglia delle enediyne (ovvero composti con tripli legami per ogni lato di un doppio legame), dotato di attivit\u00E0 antitumorale. La molecola \u00E8 un polipeptide, pi\u00F9 precisamente una apoproteina, consistente di due parti, una proteica del peso molecolare di 10.700, contenente 109 residui aminoacidici di 18 tipi differenti, e di un cromoforo, labile, di natura non proteica, con struttura biciclica, responsabile della attivit\u00E0 biologica della sostanza. Nella molecola sono presenti due ponti disolfuro tra la cisteina. L'integrit\u00E0 della struttura, ivi compreso il collegamento trasversale dei ponti disolfuro, \u00E8 essenziale per l'espletamento dell'attivit\u00E0 biologica."@it . . . . . . . . . "\u30CD\u30AA\u30AB\u30EB\u30B8\u30CE\u30B9\u30BF\u30C1\u30F3 (neocarzinostatin) \u306F\u3001Streptomyces macromomyceticus\u306B\u3088\u3063\u3066\u5206\u6CCC\u3055\u308C\u308B\u9AD8\u5206\u5B50\u30A8\u30F3\u30B8\u30A4\u30F3\u6297\u751F\u7269\u8CEA\u3067\u3042\u308B\u3002\u6297\u816B\u760D\u6D3B\u6027\u3092\u793A\u3059\u3002\u30CD\u30AA\u30AB\u30EB\u30C1\u30CE\u30B9\u30BF\u30C1\u30F3\u3068\u3082\u547C\u3070\u308C\u308B\u3002 \u30CD\u30AA\u30AB\u30EB\u30B8\u30CE\u30B9\u30BF\u30C1\u30F3\u306F\u4E0D\u5B89\u5B9A\u306A\u767A\u8272\u56E3\uFF08\u4E8C\u74B0\u6027\u30B8\u30A8\u30F3\u30B8\u30A4\u30F3\u69CB\u9020\uFF09\u3068113\u30A2\u30DF\u30CE\u9178\u304B\u3089\u306A\u308B\u30A2\u30DD\u30BF\u30F3\u30D1\u30AF\u8CEA\u306E2\u3064\u306E\u90E8\u5206\u304B\u3089\u306A\u308A\u3001\u30A2\u30DD\u30BF\u30F3\u30D1\u30AF\u8CEA\u3068\u767A\u8272\u56E3\u306F\u975E\u5171\u6709\u7D50\u5408\u7684\u306B\u3057\u3063\u304B\u308A\u3068\u9AD8\u3044\u89AA\u548C\u6027 (Kd ~ 10-10 M) \u3067\u7D50\u5408\u3057\u3066\u3044\u308B\u3002\u767A\u8272\u56E3\u306F\u975E\u5E38\u306B\u5F37\u529B\u306ADNA\u640D\u50B7\u5264\u3067\u3042\u308B\u3002\u767A\u8272\u56E3\u306F\u975E\u5E38\u306B\u4E0D\u5B89\u5B9A\u3067\u3042\u308A\u3001\u30A2\u30DD\u30BF\u30F3\u30D1\u30AF\u8CEA\u306F\u767A\u8272\u56E3\u3092\u4FDD\u8B77\u3057\u3001\u6A19\u7684\u3068\u3059\u308BDNA\u3078\u653E\u51FA\u3059\u308B\u5F79\u5272\u3092\u679C\u305F\u3057\u3066\u3044\u308B\u3002\u7D30\u80DE\u4E2D\u306B\u5B58\u5728\u3059\u308B\u9084\u5143\u7684\u6761\u4EF6\u4E0B\u3067\u306E\u30A8\u30DD\u30AD\u30B7\u30C9\u306E\u958B\u74B0\u306B\u3088\u3063\u3066\u3001\u30D0\u30FC\u30B0\u30DE\u30F3\u74B0\u5316\u306E\u305F\u3081\u306E\u6761\u4EF6\u304C\u6574\u3048\u3089\u308C\u3001\u305D\u306E\u5F8C\u30B8\u30E9\u30B8\u30AB\u30EB\u4E2D\u9593\u4F53\u306E\u7523\u751F\u3068DNA\u4E8C\u91CD\u9396\u306E\u5207\u65AD\u304C\u8D77\u3053\u308B\u3002\u305D\u306E\u4ED6\u306E\u30CD\u30AA\u30AB\u30EB\u30B8\u30CE\u30B9\u30BF\u30C1\u30F3\u985E\u6297\u751F\u7269\u8CEA\u306B\u306F\u30DE\u30AF\u30ED\u30E2\u30DF\u30B7\u30F3\u3084\u3001\u3001\u30DE\u30BA\u30ED\u30DA\u30D7\u30C1\u30F3\u304C\u3042\u308B\u3002 \u6297\u816B\u760D\u85AC\u3068\u3057\u3066\u306F\u6700\u3082\u5F37\u529B\u306A\u5316\u5408\u7269\u306E\u4E00\u3064\u3067\u3042\u308B\u3002"@ja . . . "\u30CD\u30AA\u30AB\u30EB\u30B8\u30CE\u30B9\u30BF\u30C1\u30F3 (neocarzinostatin) \u306F\u3001Streptomyces macromomyceticus\u306B\u3088\u3063\u3066\u5206\u6CCC\u3055\u308C\u308B\u9AD8\u5206\u5B50\u30A8\u30F3\u30B8\u30A4\u30F3\u6297\u751F\u7269\u8CEA\u3067\u3042\u308B\u3002\u6297\u816B\u760D\u6D3B\u6027\u3092\u793A\u3059\u3002\u30CD\u30AA\u30AB\u30EB\u30C1\u30CE\u30B9\u30BF\u30C1\u30F3\u3068\u3082\u547C\u3070\u308C\u308B\u3002 \u30CD\u30AA\u30AB\u30EB\u30B8\u30CE\u30B9\u30BF\u30C1\u30F3\u306F\u4E0D\u5B89\u5B9A\u306A\u767A\u8272\u56E3\uFF08\u4E8C\u74B0\u6027\u30B8\u30A8\u30F3\u30B8\u30A4\u30F3\u69CB\u9020\uFF09\u3068113\u30A2\u30DF\u30CE\u9178\u304B\u3089\u306A\u308B\u30A2\u30DD\u30BF\u30F3\u30D1\u30AF\u8CEA\u306E2\u3064\u306E\u90E8\u5206\u304B\u3089\u306A\u308A\u3001\u30A2\u30DD\u30BF\u30F3\u30D1\u30AF\u8CEA\u3068\u767A\u8272\u56E3\u306F\u975E\u5171\u6709\u7D50\u5408\u7684\u306B\u3057\u3063\u304B\u308A\u3068\u9AD8\u3044\u89AA\u548C\u6027 (Kd ~ 10-10 M) \u3067\u7D50\u5408\u3057\u3066\u3044\u308B\u3002\u767A\u8272\u56E3\u306F\u975E\u5E38\u306B\u5F37\u529B\u306ADNA\u640D\u50B7\u5264\u3067\u3042\u308B\u3002\u767A\u8272\u56E3\u306F\u975E\u5E38\u306B\u4E0D\u5B89\u5B9A\u3067\u3042\u308A\u3001\u30A2\u30DD\u30BF\u30F3\u30D1\u30AF\u8CEA\u306F\u767A\u8272\u56E3\u3092\u4FDD\u8B77\u3057\u3001\u6A19\u7684\u3068\u3059\u308BDNA\u3078\u653E\u51FA\u3059\u308B\u5F79\u5272\u3092\u679C\u305F\u3057\u3066\u3044\u308B\u3002\u7D30\u80DE\u4E2D\u306B\u5B58\u5728\u3059\u308B\u9084\u5143\u7684\u6761\u4EF6\u4E0B\u3067\u306E\u30A8\u30DD\u30AD\u30B7\u30C9\u306E\u958B\u74B0\u306B\u3088\u3063\u3066\u3001\u30D0\u30FC\u30B0\u30DE\u30F3\u74B0\u5316\u306E\u305F\u3081\u306E\u6761\u4EF6\u304C\u6574\u3048\u3089\u308C\u3001\u305D\u306E\u5F8C\u30B8\u30E9\u30B8\u30AB\u30EB\u4E2D\u9593\u4F53\u306E\u7523\u751F\u3068DNA\u4E8C\u91CD\u9396\u306E\u5207\u65AD\u304C\u8D77\u3053\u308B\u3002\u305D\u306E\u4ED6\u306E\u30CD\u30AA\u30AB\u30EB\u30B8\u30CE\u30B9\u30BF\u30C1\u30F3\u985E\u6297\u751F\u7269\u8CEA\u306B\u306F\u30DE\u30AF\u30ED\u30E2\u30DF\u30B7\u30F3\u3084\u3001\u3001\u30DE\u30BA\u30ED\u30DA\u30D7\u30C1\u30F3\u304C\u3042\u308B\u3002 \u6297\u816B\u760D\u85AC\u3068\u3057\u3066\u306F\u6700\u3082\u5F37\u529B\u306A\u5316\u5408\u7269\u306E\u4E00\u3064\u3067\u3042\u308B\u3002"@ja . . . . . . . "1043675321"^^ . . . . . . . . "Neocarzinostatin.png"@en . . . . . "Zinostatin (auch: Neocarzinostatin) ist ein Arzneistoff aus der Gruppe der Endiin-Antibiotika mit antineoplastischer Wirkung. Verantwortlich f\u00FCr die Antitumor-Wirkung ist ein chromophorer Teil, der nicht-kovalent an ein aus 113 Aminos\u00E4uren bestehendes Apoprotein gebunden ist. Das Chromophor ist ohne die Bindung an das Peptid chemisch instabil. Das Peptid besteht aus einer einzigen Kette. Zinostatin wird aus Kulturen von Streptomyces carcinostaticus var. F-41 gewonnen. Das Neocarzinostatin-Chromophor verursacht an der DNA Strangbr\u00FCche, bevorzugt an der Desoxyribose des Thymins."@de . .