"Pentetrazolo"@it . . . "5917"^^ . "Pentylenetetrazol, also known as pentylenetetrazole, leptazol, metrazol, pentetrazol (INN), pentamethylenetetrazol, Corazol, Cardiazol, Deumacard, or PTZ, is a drug formerly used as a circulatory and respiratory stimulant. High doses cause convulsions, as discovered by Hungarian-American neurologist and psychiatrist Ladislas J. Meduna in 1934. It has been used in convulsive therapy, and was found to be effective\u2014primarily for depression\u2014but side effects such as uncontrolled seizures were difficult to avoid. In 1939, pentylenetetrazol was replaced by electroconvulsive therapy, which is easier to administer, as the preferred method for inducing seizures in England's mental hospitals. In the US, its approval by the Food and Drug Administration was revoked in 1982. It is used in Italy as a car"@en . . "10"^^ . . . . . . "Pentetrazol"@de . "116943"^^ . "Pentylentetrazol"@cs . . . . . . "\u30DA\u30F3\u30C6\u30C8\u30E9\u30BE\u30FC\u30EB"@ja . . . . "Pentyl\u00E8net\u00E9trazole"@fr . . "CWRVKFFCRWGWCS-UHFFFAOYSA-N"@en . "Pentetrazol, INN, (Handelsname Cardiazol) ist ein bicyclisches Tetrazol-Derivat. Es wird als Kreislaufstimulans verwendet und regt die im Gehirn gelegenen Zentren der Atmung und der Herzt\u00E4tigkeit an. In hohen Dosen l\u00F6st es Kr\u00E4mpfe aus, weshalb es fr\u00FCher auch in der Schocktherapie verwendet wurde."@de . "\u30DA\u30F3\u30C6\u30C8\u30E9\u30BE\u30FC\u30EB\uFF08Pentetrazol\uFF1BPTZ\uFF09\u307E\u305F\u306F\u30DA\u30F3\u30C1\u30EC\u30F3\u30C6\u30C8\u30E9\u30BE\u30FC\u30EB\uFF08Pentylenetetrazol\uFF09\u306F\u3001\u304B\u3064\u3066\u5FAA\u74B0\u5668\u3001\u547C\u5438\u5668\u7CFB\u306E\u8208\u596E\u5264\u3068\u3057\u3066\u4F7F\u308F\u308C\u3066\u3044\u305F\u85AC\u7269\u3067\u3042\u308B\u30021934\u5E74\u306B\u30CF\u30F3\u30AC\u30EA\u30FC\u7CFB\u30A2\u30E1\u30EA\u30AB\u4EBA\u306E\u795E\u7D4C\u5B66\u8005\u30FB\u7CBE\u795E\u79D1\u533B\u306E\u306B\u3088\u308A\u3001\u9AD8\u7528\u91CF\u3067\u75D9\u6523\u3092\u8D77\u3053\u3059\u4E8B\u304C\u767A\u898B\u3055\u308C\u305F\u3053\u3068\u304B\u3089\u75D9\u6523\u7642\u6CD5\u306B\u3082\u4F7F\u7528\u3055\u308C\u305F\u3002\u3053\u308C\u306F\u4E3B\u306B\u3046\u3064\u75C5\u306B\u6709\u52B9\u3060\u3068\u5224\u660E\u3057\u305F\u304C\u5236\u5FA1\u4E0D\u80FD\u306A\u75D9\u6523\u767A\u4F5C\u7B49\u306E\u526F\u4F5C\u7528\u304C\u3042\u308A\u30011938\u5E74\u306B\u3088\u308A\u5B9F\u65BD\u304C\u5BB9\u6613\u306A\u96FB\u6C17\u75D9\u6523\u7642\u6CD5\u304C\u767A\u660E\u3055\u308C\u308B\u3068\u3059\u3050\u306B\u53D6\u3063\u3066\u4EE3\u308F\u3089\u308C\u305F\u3002\u7C73\u56FD\u3067\u306F\u30011982\u5E74\u306B\u98DF\u54C1\u533B\u85AC\u54C1\u5C40\u306B\u3088\u308B\u627F\u8A8D\u304C\u53D6\u308A\u6D88\u3055\u308C\u305F\u3002\u30A4\u30BF\u30EA\u30A2\u3067\u306F\u5FC3\u80BA\u6A5F\u80FD\u8CE6\u6D3B\u5264\u3068\u3057\u3066\u3001\u30B3\u30C7\u30A4\u30F3\u3068\u7D44\u307F\u5408\u308F\u305B\u3066\u54B3\u6B62\u3081\u85AC\u3068\u3057\u3066\u4F7F\u7528\u3055\u308C\u3066\u3044\u308B\u3002"@ja . . "AB03"@en . . "116943" . . "Il pentetrazolo, conosciuto anche come pentilenetetrazolo, metrazolo e pentametilenetetrazolo, \u00E8 un farmaco che \u00E8 stato utilizzato come stimolante circolatorio e respiratorio. Alti dosaggi possono causare, come scoperto da Ladislas Meduna nel 1934, attacchi convulsivi. La FDA ne ha revocato l'autorizzazione al commercio nel 1982, ma \u00E8 tuttora in commercio in Italia con il nome di Cardiazol Paracodina, in combinazione con diidrocodeina, in questa formulazione \u00E8 indicato come sedativo della tosse."@it . . "changed"@en . . . . "\u30DA\u30F3\u30C6\u30C8\u30E9\u30BE\u30FC\u30EB\uFF08Pentetrazol\uFF1BPTZ\uFF09\u307E\u305F\u306F\u30DA\u30F3\u30C1\u30EC\u30F3\u30C6\u30C8\u30E9\u30BE\u30FC\u30EB\uFF08Pentylenetetrazol\uFF09\u306F\u3001\u304B\u3064\u3066\u5FAA\u74B0\u5668\u3001\u547C\u5438\u5668\u7CFB\u306E\u8208\u596E\u5264\u3068\u3057\u3066\u4F7F\u308F\u308C\u3066\u3044\u305F\u85AC\u7269\u3067\u3042\u308B\u30021934\u5E74\u306B\u30CF\u30F3\u30AC\u30EA\u30FC\u7CFB\u30A2\u30E1\u30EA\u30AB\u4EBA\u306E\u795E\u7D4C\u5B66\u8005\u30FB\u7CBE\u795E\u79D1\u533B\u306E\u306B\u3088\u308A\u3001\u9AD8\u7528\u91CF\u3067\u75D9\u6523\u3092\u8D77\u3053\u3059\u4E8B\u304C\u767A\u898B\u3055\u308C\u305F\u3053\u3068\u304B\u3089\u75D9\u6523\u7642\u6CD5\u306B\u3082\u4F7F\u7528\u3055\u308C\u305F\u3002\u3053\u308C\u306F\u4E3B\u306B\u3046\u3064\u75C5\u306B\u6709\u52B9\u3060\u3068\u5224\u660E\u3057\u305F\u304C\u5236\u5FA1\u4E0D\u80FD\u306A\u75D9\u6523\u767A\u4F5C\u7B49\u306E\u526F\u4F5C\u7528\u304C\u3042\u308A\u30011938\u5E74\u306B\u3088\u308A\u5B9F\u65BD\u304C\u5BB9\u6613\u306A\u96FB\u6C17\u75D9\u6523\u7642\u6CD5\u304C\u767A\u660E\u3055\u308C\u308B\u3068\u3059\u3050\u306B\u53D6\u3063\u3066\u4EE3\u308F\u3089\u308C\u305F\u3002\u7C73\u56FD\u3067\u306F\u30011982\u5E74\u306B\u98DF\u54C1\u533B\u85AC\u54C1\u5C40\u306B\u3088\u308B\u627F\u8A8D\u304C\u53D6\u308A\u6D88\u3055\u308C\u305F\u3002\u30A4\u30BF\u30EA\u30A2\u3067\u306F\u5FC3\u80BA\u6A5F\u80FD\u8CE6\u6D3B\u5264\u3068\u3057\u3066\u3001\u30B3\u30C7\u30A4\u30F3\u3068\u7D44\u307F\u5408\u308F\u305B\u3066\u54B3\u6B62\u3081\u85AC\u3068\u3057\u3066\u4F7F\u7528\u3055\u308C\u3066\u3044\u308B\u3002"@ja . . "415933541"^^ . "Il pentetrazolo, conosciuto anche come pentilenetetrazolo, metrazolo e pentametilenetetrazolo, \u00E8 un farmaco che \u00E8 stato utilizzato come stimolante circolatorio e respiratorio. Alti dosaggi possono causare, come scoperto da Ladislas Meduna nel 1934, attacchi convulsivi. La FDA ne ha revocato l'autorizzazione al commercio nel 1982, ma \u00E8 tuttora in commercio in Italia con il nome di Cardiazol Paracodina, in combinazione con diidrocodeina, in questa formulazione \u00E8 indicato come sedativo della tosse."@it . . . "Le pentyl\u00E8net\u00E9trazole, \u00E9galement connu sous les noms des pentyl\u00E8net\u00E9trazol, m\u00E9trazol, pent\u00E9trazol, pentam\u00E9thyl\u00E8net\u00E9trazol, cardiazol ou PTZ, est un m\u00E9dicament autrefois utilis\u00E9 comme stimulant circulatoire et respiratoire. Le neurologue et psychiatre am\u00E9ricano-hongrois Ladislas J. Meduna a d\u00E9couvert en 1934 que des doses \u00E9lev\u00E9es provoquaient des convulsions. Il a ainsi \u00E9t\u00E9 utilis\u00E9 dans ce sens pour provoquer des crises pharmaco-induites par injection intraveineuse dans le cadre d'\u00E9lectroconvulsivoth\u00E9rapies, mais n'a jamais \u00E9t\u00E9 consid\u00E9r\u00E9 comme efficace, des effets secondaires du type \u00E9pilepsie \u00E9tant difficile \u00E0 \u00E9viter.Son autorisation par la Food and Drug Administration (FDA) a \u00E9t\u00E9 annul\u00E9e en 1982."@fr . . "WM5Z385K7T" . . "\u041F\u0435\u043D\u0442\u0438\u043B\u0435\u043D\u0442\u0435\u0442\u0440\u0430\u0437\u043E\u043B (\u043A\u043E\u0440\u0430\u0437\u043E\u043B, \u043C\u0435\u0442\u0440\u0430\u0437\u043E\u043B) \u2014 \u043B\u0435\u043A\u0430\u0440\u0441\u0442\u0432\u0435\u043D\u043D\u043E\u0435 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u043E, \u0440\u0430\u043D\u0435\u0435 \u0438\u0441\u043F\u043E\u043B\u044C\u0437\u043E\u0432\u0430\u0432\u0448\u0435\u0435\u0441\u044F \u043F\u0440\u0438 \u043E\u0441\u0442\u0440\u044B\u0445 \u043E\u0442\u0440\u0430\u0432\u043B\u0435\u043D\u0438\u044F\u0445 \u0441\u043D\u043E\u0442\u0432\u043E\u0440\u043D\u044B\u043C\u0438 \u0438 \u043D\u0435\u043A\u043E\u0442\u043E\u0440\u044B\u043C\u0438 \u043D\u0430\u0440\u043A\u043E\u0442\u0438\u043A\u0430\u043C\u0438 (\u0431\u0430\u0440\u0431\u0438\u0442\u0443\u0440\u0430\u0442\u0430\u043C\u0438, \u0431\u0435\u043D\u0437\u043E\u0434\u0438\u0430\u0437\u0435\u043F\u0438\u043D\u0430\u043C\u0438, \u043E\u043F\u0438\u043E\u0438\u0434\u0430\u043C\u0438)."@ru . . . "changed"@en . "File:Pentylenetetrazol ball-and-stick model.png"@en . . "WM5Z385K7T"@en . "D07409"@en . . "Le pentyl\u00E8net\u00E9trazole, \u00E9galement connu sous les noms des pentyl\u00E8net\u00E9trazol, m\u00E9trazol, pent\u00E9trazol, pentam\u00E9thyl\u00E8net\u00E9trazol, cardiazol ou PTZ, est un m\u00E9dicament autrefois utilis\u00E9 comme stimulant circulatoire et respiratoire. Le neurologue et psychiatre am\u00E9ricano-hongrois Ladislas J. Meduna a d\u00E9couvert en 1934 que des doses \u00E9lev\u00E9es provoquaient des convulsions. Il a ainsi \u00E9t\u00E9 utilis\u00E9 dans ce sens pour provoquer des crises pharmaco-induites par injection intraveineuse dans le cadre d'\u00E9lectroconvulsivoth\u00E9rapies, mais n'a jamais \u00E9t\u00E9 consid\u00E9r\u00E9 comme efficace, des effets secondaires du type \u00E9pilepsie \u00E9tant difficile \u00E0 \u00E9viter.Son autorisation par la Food and Drug Administration (FDA) a \u00E9t\u00E9 annul\u00E9e en 1982."@fr . "150"^^ . "6789"^^ . . "Pentylentetrazol, zvan\u00FD t\u00E9\u017E metrazol, pentetrazol, pentamethylentetrazol, nebo zkratkou PTZ je heterocyklick\u00E1 organick\u00E1 chemick\u00E1 l\u00E1tka pou\u017E\u00EDvan\u00E1 jako l\u00E9\u010Divo stimuluj\u00EDc\u00ED d\u00FDch\u00E1n\u00ED a cirkulaci krve. Jak objevil v roce 1934 , ma\u010Farsk\u00FD neurolog \u017Eij\u00EDc\u00ED v USA, zp\u016Fsobuje tato l\u00E1tka ve vysok\u00FDch d\u00E1vk\u00E1ch k\u0159e\u010De a z\u00E1chvaty podobn\u00E9 epileptick\u00FDm i u osob bez p\u0159ede\u0161l\u00E9 historie takov\u00FDch z\u00E1chvat\u016F a netrp\u00EDc\u00EDch tud\u00ED\u017E epilepsi\u00ED (padoucnic\u00ED), jedn\u00E1 se tedy o tzv. \u2013 l\u00E1tku zp\u016Fsobuj\u00EDc\u00ED konvulze \u2013 k\u0159e\u010De. Konvulzivn\u00ED vlastnosti metrazolu bylo d\u0159\u00EDve vyu\u017E\u00EDv\u00E1no k tzv. konvulzivn\u00ED terapii psychick\u00FDch onemocn\u011Bn\u00ED, p\u0159edev\u0161\u00EDm byla terapie metrazolem \u00FA\u010Dinn\u00E1 pro onemocn\u011Bn\u00ED depresivn\u00EDho charakteru. Tato terapie byla \u00FA\u010Dinn\u00E1 a rychle odstra\u0148ovala p\u0159\u00EDznaky, zejm\u00E9na pr\u00E1v\u011B depresivn\u00EDch onemocn\u011Bn\u00ED. Bylo v\u0161ak t\u011B\u017Ek\u00E9 a mnohdy nemo\u017En\u00E9 p\u0159edej\u00EDt po pod\u00E1n\u00ED konvulzivn\u00ED d\u00E1vky dlouhotrvaj\u00EDc\u00EDm a nekontrolovateln\u00FDm k\u0159e\u010D\u00EDm a z\u00E1chvat\u016Fm, a tak byla konvulzivn\u00ED terapie metrazolem opu\u0161t\u011Bna a nahrazena terapi\u00ED elektrokonvulzivn\u00ED, p\u0159i kter\u00E9 z\u00E1chvaty trvaj\u00ED krat\u0161\u00ED dobu, jsou kontrolovateln\u011Bj\u0161\u00ED a maj\u00ED stejn\u011B hodnotn\u00FD terapeutick\u00FD \u00FA\u010Dinek, nav\u00EDc s \u0161ir\u0161\u00EDm spektrem \u00FA\u010Dinnosti \u2013 t\u00E9\u017E se u\u017E\u00EDv\u00E1 k terapii manick\u00FDch a psychotick\u00FDch p\u0159\u00EDznak\u016F."@cs . . . "El pentilenotetrazol (tambi\u00E9n pentilentetrazol, Pentetrazol o su marca registrada Metrazol\u00AE) es un f\u00E1rmaco de acci\u00F3n estimulante del sistema nervioso central muy potente que se ha prescrito como anal\u00E9ptico para estimular el centro respiratorio, vagal y vasomotor del cerebro, para contrarrestar los efectos de los depresores y para incrementar el flujo sangu\u00EDneo cerebral, especialmente en pacientes geri\u00E1tricos. En ingl\u00E9s, es conocido con el nombre de Pentylenetetrazol.\u200B"@es . "54"^^ . . . . . . "7252"^^ . . "\u041F\u0435\u043D\u0442\u0438\u043B\u0435\u043D\u0442\u0435\u0442\u0440\u0430\u0437\u043E\u043B"@ru . "Metrazol, others"@en . . . . . . . . . . . . "Pentilenotetrazol"@es . "1"^^ . "34910" . . "6"^^ . "El pentilenotetrazol (tambi\u00E9n pentilentetrazol, Pentetrazol o su marca registrada Metrazol\u00AE) es un f\u00E1rmaco de acci\u00F3n estimulante del sistema nervioso central muy potente que se ha prescrito como anal\u00E9ptico para estimular el centro respiratorio, vagal y vasomotor del cerebro, para contrarrestar los efectos de los depresores y para incrementar el flujo sangu\u00EDneo cerebral, especialmente en pacientes geri\u00E1tricos. En ingl\u00E9s, es conocido con el nombre de Pentylenetetrazol.\u200B"@es . . "54-95-5" . . . "C1CCc2nnnn2CC1"@en . . "Pentylenetetrazol"@en . . "\u041F\u0435\u043D\u0442\u0438\u043B\u0435\u043D\u0442\u0435\u0442\u0440\u0430\u0437\u043E\u043B (\u043A\u043E\u0440\u0430\u0437\u043E\u043B, \u043C\u0435\u0442\u0440\u0430\u0437\u043E\u043B) \u2014 \u043B\u0435\u043A\u0430\u0440\u0441\u0442\u0432\u0435\u043D\u043D\u043E\u0435 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u043E, \u0440\u0430\u043D\u0435\u0435 \u0438\u0441\u043F\u043E\u043B\u044C\u0437\u043E\u0432\u0430\u0432\u0448\u0435\u0435\u0441\u044F \u043F\u0440\u0438 \u043E\u0441\u0442\u0440\u044B\u0445 \u043E\u0442\u0440\u0430\u0432\u043B\u0435\u043D\u0438\u044F\u0445 \u0441\u043D\u043E\u0442\u0432\u043E\u0440\u043D\u044B\u043C\u0438 \u0438 \u043D\u0435\u043A\u043E\u0442\u043E\u0440\u044B\u043C\u0438 \u043D\u0430\u0440\u043A\u043E\u0442\u0438\u043A\u0430\u043C\u0438 (\u0431\u0430\u0440\u0431\u0438\u0442\u0443\u0440\u0430\u0442\u0430\u043C\u0438, \u0431\u0435\u043D\u0437\u043E\u0434\u0438\u0430\u0437\u0435\u043F\u0438\u043D\u0430\u043C\u0438, \u043E\u043F\u0438\u043E\u0438\u0434\u0430\u043C\u0438)."@ru . . . . "Metrazol, others"@en . "Pentylenetetrazol, also known as pentylenetetrazole, leptazol, metrazol, pentetrazol (INN), pentamethylenetetrazol, Corazol, Cardiazol, Deumacard, or PTZ, is a drug formerly used as a circulatory and respiratory stimulant. High doses cause convulsions, as discovered by Hungarian-American neurologist and psychiatrist Ladislas J. Meduna in 1934. It has been used in convulsive therapy, and was found to be effective\u2014primarily for depression\u2014but side effects such as uncontrolled seizures were difficult to avoid. In 1939, pentylenetetrazol was replaced by electroconvulsive therapy, which is easier to administer, as the preferred method for inducing seizures in England's mental hospitals. In the US, its approval by the Food and Drug Administration was revoked in 1982. It is used in Italy as a cardio-respiratory stimulant in combination with codeine in a cough suppressant drug."@en . . . . "30873297"^^ . "Pentetrazol, INN, (Handelsname Cardiazol) ist ein bicyclisches Tetrazol-Derivat. Es wird als Kreislaufstimulans verwendet und regt die im Gehirn gelegenen Zentren der Atmung und der Herzt\u00E4tigkeit an. In hohen Dosen l\u00F6st es Kr\u00E4mpfe aus, weshalb es fr\u00FCher auch in der Schocktherapie verwendet wurde."@de . . . . "5917" . "1112210003"^^ . . . "4"^^ . . . "Pentylentetrazol, zvan\u00FD t\u00E9\u017E metrazol, pentetrazol, pentamethylentetrazol, nebo zkratkou PTZ je heterocyklick\u00E1 organick\u00E1 chemick\u00E1 l\u00E1tka pou\u017E\u00EDvan\u00E1 jako l\u00E9\u010Divo stimuluj\u00EDc\u00ED d\u00FDch\u00E1n\u00ED a cirkulaci krve. Jak objevil v roce 1934 , ma\u010Farsk\u00FD neurolog \u017Eij\u00EDc\u00ED v USA, zp\u016Fsobuje tato l\u00E1tka ve vysok\u00FDch d\u00E1vk\u00E1ch k\u0159e\u010De a z\u00E1chvaty podobn\u00E9 epileptick\u00FDm i u osob bez p\u0159ede\u0161l\u00E9 historie takov\u00FDch z\u00E1chvat\u016F a netrp\u00EDc\u00EDch tud\u00ED\u017E epilepsi\u00ED (padoucnic\u00ED), jedn\u00E1 se tedy o tzv. \u2013 l\u00E1tku zp\u016Fsobuj\u00EDc\u00ED konvulze \u2013 k\u0159e\u010De. Konvulzivn\u00ED vlastnosti metrazolu bylo d\u0159\u00EDve vyu\u017E\u00EDv\u00E1no k tzv. konvulzivn\u00ED terapii psychick\u00FDch onemocn\u011Bn\u00ED, p\u0159edev\u0161\u00EDm byla terapie metrazolem \u00FA\u010Dinn\u00E1 pro onemocn\u011Bn\u00ED depresivn\u00EDho charakteru. Tato terapie byla \u00FA\u010Dinn\u00E1 a rychle odstra\u0148ovala p\u0159\u00EDznaky, zejm\u00E9na pr\u00E1v\u011B depresivn\u00EDch onemocn\u011Bn\u00ED. Bylo v\u0161ak t\u011B\u017Ek\u00E9 a mnohdy nemo\u017En\u00E9 p"@cs . . "D07409" . . . "R07"@en . "5704"^^ . "34910"^^ . . . . . . .