. . "552755"^^ . . . "La esteatosis o cambio graso es el nombre que recibe en anatom\u00EDa patol\u00F3gica la acumulaci\u00F3n anormal de triglic\u00E9ridos en el citoplasma de c\u00E9lulas parenquimatosas. Lo m\u00E1s frecuente es que se d\u00E9 en el h\u00EDgado (esteatosis hep\u00E1tica), pero tambi\u00E9n aparece en coraz\u00F3n, ri\u00F1\u00F3n, etc.\u200B Es una lesi\u00F3n reversible.\u200B Los factores de riesgo asociados a la esteatosis son variados, y pueden incluir la diabetes mellitus, desnutrici\u00F3n proteica, hipertensi\u00F3n arterial,\u200B toxinas, obesidad,\u200B y la apnea del sue\u00F1o.\u200B"@es . . "1107950369"^^ . . "La steatozo a\u016D grasa \u015Dan\u011Do estas la nomo kiun ricevas en anatomia patologio la nenormala akumulado de trigliceridoj en la citoplasmo de parenkimaj \u0109eloj. Plej ofte okazas en la hepato (hepata steatozo), sed aperas anka\u016D en koro, reno ktp. Temas pri inversigebla misordo. La riskofaktoroj asociaj al la steatozo estas variaj, kaj povas esti la diabeto mellitus, la protea malnutrado, la arteria hipertensio, toksinoj, obezeco, kaj la dormapneo. La lipidoj akumuli\u011Das en vezikoj kiuj, depende de sia grando, klasigas la steatozojn en mikrovezikaj a\u016D makrovezikaj. En tiuj lastaj, la kvanto de grasoj estas tiom granda ke ili okupas la tutan citoplasmon kaj movas la kernon al la periferio."@eo . . . . "Steatosi"@it . . . . "\u8102\u80AA\u5909\u6027\uFF08\u3057\u307C\u3046\u3078\u3093\u305B\u3044\u3001\u82F1:fatty degeneration\uFF09\u3068\u306F\u7D30\u80DE\u8CEA\u5185\u306B\u5F62\u614B\u5B66\u7684\u306B\u89B3\u5BDF\u53EF\u80FD\u306A\u304C\u51FA\u73FE\u3057\u3066\u3044\u308B\u72B6\u614B\u3002\u8102\u80AA\u5316\u3068\u3082\u547C\u3070\u308C\u308B\u3002\u8102\u80AA\u5909\u6027\u306F\u4E2D\u6027\u8102\u80AA\u306E\u7570\u5E38\u84C4\u7A4D\u306B\u3088\u308A\u51FA\u73FE\u3059\u308B\u3002\u30D1\u30E9\u30D5\u30A3\u30F3\u5207\u7247\u3067\u306F\u305D\u306E\u4F5C\u6210\u904E\u7A0B\u3067\u8102\u80AA\u3084\u8102\u8CEA\u304C\u6EB6\u51FA\u3055\u308C\u308B\u305F\u3081\u3001\u8102\u80AA\u6EF4\u306F\u7A7A\u80DE\u3068\u3057\u3066\u89B3\u5BDF\u3055\u308C\u308B\u3002\u8102\u80AA\u5909\u6027\u306E\u8B58\u5225\u306B\u306F\u51CD\u7D50\u5207\u7247\u306B\u3088\u308B\u8102\u80AA\u67D3\u8272\u304C\u5FC5\u8981\u3067\u3042\u308A\u3001\u4E2D\u6027\u8102\u80AA\u306F\u30BA\u30C0\u30F3III\u3067\u306F\u6A59\u8272\u3001Oil-red-O\u67D3\u8272\u3067\u306F\u7D05\u8272\u3001\u30CA\u30A4\u30EB\u9752\u3067\u306F\u8D64\u8272\u3001\u30AA\u30B9\u30DF\u30A6\u30E0\u9178\u3067\u306F\u9ED2\u8272\u306B\u67D3\u307E\u308B\u3002"@ja . . . . . . . . . . "Steatosis"@en . . . . . . . . . . "\u8102\u80AA\u5909\u6027"@ja . . . . 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"Xxx.x" . . . . . 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"Micrograph demonstrating marked steatosis in non-alcoholic fatty liver disease. Masson's trichrome stain."@en . . "Steatosis, also called fatty change, is abnormal retention of fat (lipids) within a cell or organ. Steatosis most often affects the liver \u2013 the primary organ of lipid metabolism \u2013 where the condition is commonly referred to as fatty liver disease. Steatosis can also occur in other organs, including the kidneys, heart, and muscle. When the term is not further specified (as, for example, in 'cardiac steatosis'), it is assumed to refer to the liver. Risk factors associated with steatosis are varied, and may include diabetes mellitus, protein malnutrition, hypertension, cell toxins, obesity, anoxia, and sleep apnea. Steatosis reflects an impairment of the normal processes of synthesis and elimination of triglyceride fat. Excess lipid accumulates in vesicles that displace the cytoplasm. When the vesicles are large enough to distort the nucleus, the condition is known as macrovesicular steatosis; otherwise, the condition is known as microvesicular steatosis. While not particularly detrimental to the cell in mild cases, large accumulations can disrupt cell constituents, and in severe cases the cell may even burst."@en . "Steatozo"@eo . "Esteatose"@pt . . . . "Esteatose, tamb\u00E9m chamada de transforma\u00E7\u00E3o gordurosa ou lipidose \u00E9 uma degenera\u00E7\u00E3o caracterizada pelo ac\u00FAmulo anormal e revers\u00EDvel de lip\u00EDdeos no citoplasma de c\u00E9lulas parenquimatosas, hepat\u00F3citos, fibras do mioc\u00E1rdio, onde normalmente lip\u00EDdeos n\u00E3o seriam evidenciados histologicamente, formando vac\u00FAolos em conseq\u00FC\u00EAncia de desequil\u00EDbrios na s\u00EDntese, utiliza\u00E7\u00E3o ou mobiliza\u00E7\u00E3o. A cirrose de causa indefinida (criptog\u00EAnica) onde observa-se esteatose, mas n\u00E3o h\u00E1 sinais de EHNA ativa, tamb\u00E9m est\u00E1 classificada como DHGNA. - Epidemiologia -Etiologia -Esteatose"@pt . . "Steatosis, also called fatty change, is abnormal retention of fat (lipids) within a cell or organ. Steatosis most often affects the liver \u2013 the primary organ of lipid metabolism \u2013 where the condition is commonly referred to as fatty liver disease. Steatosis can also occur in other organs, including the kidneys, heart, and muscle. When the term is not further specified (as, for example, in 'cardiac steatosis'), it is assumed to refer to the liver."@en . . . . ""@en . "14154"^^ . "Steatosis"@en . "xxx"@en . . . . . "Esteatosis"@es . . . . "xxx" . . . "Esteatose, tamb\u00E9m chamada de transforma\u00E7\u00E3o gordurosa ou lipidose \u00E9 uma degenera\u00E7\u00E3o caracterizada pelo ac\u00FAmulo anormal e revers\u00EDvel de lip\u00EDdeos no citoplasma de c\u00E9lulas parenquimatosas, hepat\u00F3citos, fibras do mioc\u00E1rdio, onde normalmente lip\u00EDdeos n\u00E3o seriam evidenciados histologicamente, formando vac\u00FAolos em conseq\u00FC\u00EAncia de desequil\u00EDbrios na s\u00EDntese, utiliza\u00E7\u00E3o ou mobiliza\u00E7\u00E3o. Como o f\u00EDgado \u00E9 o \u00F3rg\u00E3o diretamente relacionado com o metabolismo lip\u00EDdico, \u00E9 nele que vamos encontrar mais comumente a esteatose. A esteato-hepatite n\u00E3o-alco\u00F3lica (EHNA, ou NASH, do ingl\u00EAs \"nonalcoholic steatohepatitis\") \u00E9 uma doen\u00E7a hep\u00E1tica gordurosa n\u00E3o alco\u00F3lica (DHGNA) onde a presen\u00E7a da esteatose est\u00E1 relacionada a uma inflama\u00E7\u00E3o no f\u00EDgado (hepatite). Assim, a esteatose hep\u00E1tica (\"f\u00EDgado gorduroso\") e a EHNA s\u00E3o apresenta\u00E7\u00F5es diferentes da DHGNA, sendo que a primeira pode evoluir para a segunda. A cirrose de causa indefinida (criptog\u00EAnica) onde observa-se esteatose, mas n\u00E3o h\u00E1 sinais de EHNA ativa, tamb\u00E9m est\u00E1 classificada como DHGNA. A DHGNA \u00E9 o conjunto de doen\u00E7as gordurosas do f\u00EDgado n\u00E3o relacionadas ao uso de \u00E1lcool. A esteatose hep\u00E1tica, ou \"f\u00EDgado gorduroso\", \u00E9 o simples ac\u00FAmulo de gorduras nas c\u00E9lulas do f\u00EDgado, enquanto que a esteato-hepatite \u00E9 o ac\u00FAmulo de gorduras com inflama\u00E7\u00E3o do f\u00EDgado. N\u00E3o h\u00E1 nenhum exame que distingue a esteatose decorrente do uso de \u00E1lcool da DHGNA, portanto s\u00F3 podemos considerar como DHGNA se n\u00E3o houver hist\u00F3rico de uso de \u00E1lcool ou se a quantidade ingerida for insuficiente para causar a esteatose. Geralmente considera-se que um consumo inferior a 20 gramas de \u00E1lcool por semana seria seguro, mas pessoalmente considero que a varia\u00E7\u00E3o na sensibilidade individual exige a abstin\u00EAncia completa de qualquer quantidade de \u00E1lcool por no m\u00EDnimo 3 meses para excluir a influ\u00EAncia desse. Hoje, o termo DHGNA j\u00E1 \u00E9 insuficiente para descrever essa patologia. J\u00E1 temos mais informa\u00E7\u00F5es sobre situa\u00E7\u00F5es completamente diferentes que podem levar \u00E0 inflama\u00E7\u00E3o observada na EHNA, com progn\u00F3sticos e tratamentos distintos. H\u00E1 uma tend\u00EAncia a se considerar como DHGNA apenas as esteatoses relacionadas a s\u00EDndrome metab\u00F3lica, mas atualmente a defini\u00E7\u00E3o acima se mant\u00E9m. - Epidemiologia Avaliar quantas pessoas s\u00E3o portadoras de DHGNA \u00E9 dif\u00EDcil, n\u00E3o h\u00E1 nenhum m\u00E9todo pr\u00F3ximo do ideal para realizar essa investiga\u00E7\u00E3o. O m\u00E9todo mais simples \u00E9 a realiza\u00E7\u00E3o de ultrassonografia, que demonstra achados sugestivos de esteatose (\"f\u00EDgado brilhante\") em mais de 16% das pessoas saud\u00E1veis n\u00E3o obesas e em cerca de 95% dos obesos que fazem uso de \u00E1lcool. Outros pesquisadores procuraram determinar a porcentagem de portadores na popula\u00E7\u00E3o a partir de dados de necr\u00F3psia (exames em cad\u00E1veres) ou outros m\u00E9todos de imagem, como tomografia computadorizada e resson\u00E2ncia nuclear magn\u00E9tica, mas nenhum dos exames de imagem pode diferenciar com seguran\u00E7a apenas a esteatose de esteato-hepatite. -Etiologia Muitas doen\u00E7as podem se manifestar no f\u00EDgado como esteatose associada ou n\u00E3o \u00E0 inflama\u00E7\u00E3o. Algumas est\u00E3o associadas a dist\u00FArbios no metabolismo de gordura em todo o organismo com o ac\u00FAmulo de gordura no f\u00EDgado, mas n\u00E3o necessariamente. Medicamentos e subst\u00E2ncias t\u00F3xicas como a tetraciclina podem levar a inflama\u00E7\u00E3o e degenera\u00E7\u00E3o gordurosa do f\u00EDgado atrav\u00E9s de les\u00E3o nas mitoc\u00F4ndrias do f\u00EDgado, levando \u00E0 incapacidade de metabolizar adequadamente as gorduras no \u00F3rg\u00E3o e ainda levar \u00E0 destrui\u00E7\u00E3o de c\u00E9lulas e inflama\u00E7\u00E3o. Outras doen\u00E7as como as doen\u00E7as inflamat\u00F3rias intestinais (doen\u00E7a de Crohn, retocolite ulcerativa) podem causar esteatose e inflama\u00E7\u00E3o pelo aumento de prote\u00EDnas inflamat\u00F3rias e produtos bacterianos que chegam ao f\u00EDgado pela veia porta. Outras ainda podem ser erroneamente diagnosticadas como esteatose por confundirem exames de imagem (como a doen\u00E7a de Wilson e a hemocromatose), ou o an\u00E1tomo-patol\u00F3gico (como nas glicogenoses, onde o ac\u00FAmulo de glicog\u00EAnio pode ser confundido com esteatose tanto na bi\u00F3psia quanto nos exames de imagem). -Esteatose O ac\u00FAmulo de gordura no interior dos hepat\u00F3citos \u00E9 um mecanismo natural, utilizado para estocar energia. A quantidade de energia acumulada na gordura \u00E9 muito maior que no a\u00E7\u00FAcar ou na prote\u00EDna, podendo fornecer ao organismo grande quantidade de energia nos momentos de necessidade. O f\u00EDgado mant\u00E9m dois grandes estoques de energia: a gordura (especialmente na forma de triglic\u00E9rides, tamb\u00E9m chamados de triacilglicer\u00F3is) e o glicog\u00EAnio, que \u00E9 uma glicose alterada para ser estocada. Quando permanecemos em jejum e o n\u00EDvel de a\u00E7\u00FAcar no sangue diminui, horm\u00F4nios enviam sinal ao f\u00EDgado para transformar o glicog\u00EAnio em glicose e manter o organismo funcionando. Se a falta de comida persistir, a gordura come\u00E7a a ser utilizada, mas este processo \u00E9 mais demorado. Al\u00E9m disso, estudos sugerem que as c\u00E9lulas esteladas do f\u00EDgado tentam controlar os n\u00EDveis de colesterol no sangue transportando o excesso de gorduras para dentro do f\u00EDgado. Os coelhos, por exemplo, que n\u00E3o tem c\u00E9lulas esteladas, sofrem muito mais com o excesso de colesterol. -H\u00E1 v\u00E1rios motivos pelos quais o metabolismo natural de gordura pode ser alterado e levar \u00E0 DHGNA:O mais estudado est\u00E1 relacionado a resist\u00EAncia dos tecidos ao horm\u00F4nio insulina, que regula e influencia todos os processos metab\u00F3licos que envolvem a\u00E7\u00FAcares e gorduras. Com a resist\u00EAncia \u00E0 insulina, h\u00E1 aumento da lip\u00F3lise (transforma\u00E7\u00E3o dos lip\u00EDdeos em \u00E1cidos graxos, especialmente na forma de triglic\u00E9rides), com o aumento no aporte de \u00E1cidos graxos ao f\u00EDgado.(Triglic\u00E9rides s\u00E3o mol\u00E9culas formadas por uma mol\u00E9cula de glicerol esterificada a tr\u00EAs mol\u00E9culas de \u00E1cidos graxos. Na figura, o glicerol est\u00E1 \u00E0 esquerda e os tr\u00EAs \u00E1cidos graxos, de cima para baixo, s\u00E3o \u00E1cido palm\u00EDtico, \u00E1cido ol\u00E9ico e \u00E1cido alfa-linol\u00E9ico. Os triglic\u00E9rides s\u00E3o \"desmontados\" no intestino, absorvidos e depois podem ser novamente montados no f\u00EDgado e depositados neste ou nas c\u00E9lulas de gordura, aonde normalmente tem a fun\u00E7\u00E3o prim\u00E1ria de servir como reserva de energia.)A dieta rica em carboidratos, por oferecer grande quantidade de energia, permite ao organismo estocar a energia excedente, principalmente na forma de triglic\u00E9rides (a presen\u00E7a de triglic\u00E9rides em grande quantidade no organismo n\u00E3o significa necessariamente a ingest\u00E3o de grande quantidade de gordura, pois mesmo dietas com pouca gordura, em pessoas com dist\u00FArbios metab\u00F3licos que estimulam a produ\u00E7\u00E3o de gorduras no organismo, poder\u00E3o apresentar n\u00EDveis assustadoramente altos de lip\u00EDdeos), que s\u00E3o produzidos e acumulados no f\u00EDgado.A metaboliza\u00E7\u00E3o de \u00E1cidos graxos, realizada em grande parte no interior das mitoc\u00F4ndrias, pode estar prejudicado. Essa hip\u00F3tese \u00E9 sustentada pela demonstra\u00E7\u00E3o de redu\u00E7\u00E3o na atividade de genes que atuam na fun\u00E7\u00E3o mitocondrial em portadores de EHNA. A pr\u00F3pria esteatose pode levar a um processo de retroalimenta\u00E7\u00E3o positiva (\"c\u00EDrculo vicioso\") que estimula os processos anteriores.Estudos recentes est\u00E3o ajudando a esclarecer porque o grau de obesidade e de hipertrigliceridemia (excesso de triglic\u00E9rides) n\u00E3o est\u00E1 necessariamente relacionado \u00E0 presen\u00E7a de esteatose e esteato-hepatite e porque h\u00E1 uma tend\u00EAncia a familiares de portadores de DHGNA e EHNA a terem maior risco da doen\u00E7a do que pessoas semelhantes. Diversos genes foram relacionados \u00E0 maior risco de DHGNA, mas ainda resta saber como esses genes desencadeiam a doen\u00E7a e, mais importante, se dist\u00FArbios gen\u00E9ticos diferentes dar\u00E3o origem a tratamentos espec\u00EDficos e mais eficazes para cada situa\u00E7\u00E3o."@pt . "La steatosi \u00E8 una patologia cellulare legata all'accumulo intracellulare di trigliceridi che comporta una serie di danni fino alla necrosi della cellula."@it . . . . . . . . . . "Fatty change, fatty degeneration, adipose degeneration"@en . . . . . . . . "La steatosi \u00E8 una patologia cellulare legata all'accumulo intracellulare di trigliceridi che comporta una serie di danni fino alla necrosi della cellula."@it . . . "Steatosis"@en . . . . . . . . . . . "La esteatosis o cambio graso es el nombre que recibe en anatom\u00EDa patol\u00F3gica la acumulaci\u00F3n anormal de triglic\u00E9ridos en el citoplasma de c\u00E9lulas parenquimatosas. Lo m\u00E1s frecuente es que se d\u00E9 en el h\u00EDgado (esteatosis hep\u00E1tica), pero tambi\u00E9n aparece en coraz\u00F3n, ri\u00F1\u00F3n, etc.\u200B Es una lesi\u00F3n reversible.\u200B Los factores de riesgo asociados a la esteatosis son variados, y pueden incluir la diabetes mellitus, desnutrici\u00F3n proteica, hipertensi\u00F3n arterial,\u200B toxinas, obesidad,\u200B y la apnea del sue\u00F1o.\u200B Los l\u00EDpidos se acumulan en ves\u00EDculas que, dependiendo de su tama\u00F1o, clasifican la esteatosis en microvesicular o macrovesicular. En esta \u00FAltima, la cantidad de grasas es tan grande que ocupan todo el citoplasma y desplazan el n\u00FAcleo a la periferia.\u200B"@es . . . . . . . . "Xxx.x"@en . . . 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"\u062A\u0646\u0643\u0633 \u062F\u0647\u0646\u064A"@ar . . . . "Fatty liver disease" . . . . . . . . . . . "La steatozo a\u016D grasa \u015Dan\u011Do estas la nomo kiun ricevas en anatomia patologio la nenormala akumulado de trigliceridoj en la citoplasmo de parenkimaj \u0109eloj. Plej ofte okazas en la hepato (hepata steatozo), sed aperas anka\u016D en koro, reno ktp. Temas pri inversigebla misordo. La riskofaktoroj asociaj al la steatozo estas variaj, kaj povas esti la diabeto mellitus, la protea malnutrado, la arteria hipertensio, toksinoj, obezeco, kaj la dormapneo."@eo . .