"\u30C8\u30EA\u30D7\u30C8\u30EA\u30C9\uFF08\u82F1:Triptolide\uFF09\u306FPG490\u3068\u3082\u547C\u3070\u308C\u308B\u30B8\u30C6\u30EB\u30DA\u30F3\u3067\u3042\u308A\u3001\u5206\u5B50\u4E2D\u306B3\u3064\u306E\u30A8\u30DD\u30AD\u30B7\u57FA\u3092\u6709\u3057\u3066\u3044\u308B\u3002\u4E2D\u56FD\u539F\u7523\u306E\u30CB\u30B7\u30AD\u30AE\u79D1\u306E\u3064\u308B\u690D\u7269\u3067\u3042\u308B\uFF08Tripterygium wilfordii\uFF09\u306B\u542B\u307E\u308C\u308B\u6210\u5206\u3067\u3042\u308A\u3001\u6F22\u65B9\u85AC\u3068\u3057\u3066\u306F\u96F7\u516C\u85E4\uFF08\uFF09\u306E\u4E3B\u8981\u6210\u5206\u3067\u3042\u308B\u3002 \u30C8\u30EA\u30D7\u30C8\u30EA\u30C9\u306F\u6297\u816B\u760D\u52B9\u679C\u306E\u4ED6\u3001\u514D\u75AB\u6291\u5236\u4F5C\u7528\u3084\u6297\u708E\u75C7\u52B9\u679C\u3092\u6301\u3064\u3002 in vitro \u3068in vivo \u3067\u591A\u767A\u6027\u56A2\u80DE\u814E\u3084\u81B5\u764C\u306E\u30DE\u30A6\u30B9\u30E2\u30C7\u30EB\u306B\u6709\u52B9\u6027\u3092\u793A\u3057\u305F\u304C\u3001\u305D\u306E\u7279\u6027\u3084\u5F37\u3044\u6BD2\u6027\u306E\u554F\u984C\u304B\u3089\u3001\u6CBB\u7642\u85AC\u3068\u3057\u3066\u306E\u4F7F\u7528\u306F\u56F0\u96E3\u3067\u3042\u308B\u3002 \u30C8\u30EA\u30D7\u30C8\u30EA\u30C9\u306B\u4EE3\u308F\u308A\u3001\u305D\u306E\u6C34\u6EB6\u6027\u30D7\u30ED\u30C9\u30E9\u30C3\u30B0\u3067\u3042\u308B\u30DF\u30F3\u30CD\u30EA\u30C9\uFF08\u82F1:Minnelide\uFF09\uFF08\u4E0B\u8A18\u53C2\u7167\uFF09\u306E\u81E8\u5E8A\u8A66\u9A13\u304C\u9032\u884C\u4E2D\u3067\u3042\u308B\u3002"@ja . . . . . "9226"^^ . . . . "Triptolid, auch PG490 genannt, ist ein in der chinesischen Kletterpflanze Wilfords Dreifl\u00FCgelfrucht (Tripterygium wilfordii) enthaltenes Diterpen mit drei Epoxid-Gruppen."@de . . "Triptolide"@en . . . . . . . "Triptolide"@es . . . . . "\u30C8\u30EA\u30D7\u30C8\u30EA\u30C9\uFF08\u82F1:Triptolide\uFF09\u306FPG490\u3068\u3082\u547C\u3070\u308C\u308B\u30B8\u30C6\u30EB\u30DA\u30F3\u3067\u3042\u308A\u3001\u5206\u5B50\u4E2D\u306B3\u3064\u306E\u30A8\u30DD\u30AD\u30B7\u57FA\u3092\u6709\u3057\u3066\u3044\u308B\u3002\u4E2D\u56FD\u539F\u7523\u306E\u30CB\u30B7\u30AD\u30AE\u79D1\u306E\u3064\u308B\u690D\u7269\u3067\u3042\u308B\uFF08Tripterygium wilfordii\uFF09\u306B\u542B\u307E\u308C\u308B\u6210\u5206\u3067\u3042\u308A\u3001\u6F22\u65B9\u85AC\u3068\u3057\u3066\u306F\u96F7\u516C\u85E4\uFF08\uFF09\u306E\u4E3B\u8981\u6210\u5206\u3067\u3042\u308B\u3002 \u30C8\u30EA\u30D7\u30C8\u30EA\u30C9\u306F\u6297\u816B\u760D\u52B9\u679C\u306E\u4ED6\u3001\u514D\u75AB\u6291\u5236\u4F5C\u7528\u3084\u6297\u708E\u75C7\u52B9\u679C\u3092\u6301\u3064\u3002 in vitro \u3068in vivo \u3067\u591A\u767A\u6027\u56A2\u80DE\u814E\u3084\u81B5\u764C\u306E\u30DE\u30A6\u30B9\u30E2\u30C7\u30EB\u306B\u6709\u52B9\u6027\u3092\u793A\u3057\u305F\u304C\u3001\u305D\u306E\u7279\u6027\u3084\u5F37\u3044\u6BD2\u6027\u306E\u554F\u984C\u304B\u3089\u3001\u6CBB\u7642\u85AC\u3068\u3057\u3066\u306E\u4F7F\u7528\u306F\u56F0\u96E3\u3067\u3042\u308B\u3002 \u30C8\u30EA\u30D7\u30C8\u30EA\u30C9\u306B\u4EE3\u308F\u308A\u3001\u305D\u306E\u6C34\u6EB6\u6027\u30D7\u30ED\u30C9\u30E9\u30C3\u30B0\u3067\u3042\u308B\u30DF\u30F3\u30CD\u30EA\u30C9\uFF08\u82F1:Minnelide\uFF09\uFF08\u4E0B\u8A18\u53C2\u7167\uFF09\u306E\u81E8\u5E8A\u8A66\u9A13\u304C\u9032\u884C\u4E2D\u3067\u3042\u308B\u3002"@ja . . . . . . . . . . . . . "Triptolid, auch PG490 genannt, ist ein in der chinesischen Kletterpflanze Wilfords Dreifl\u00FCgelfrucht (Tripterygium wilfordii) enthaltenes Diterpen mit drei Epoxid-Gruppen."@de . . . "Il triptolide \u00E8 un epossido diterpenoide trovato nella pianta . Mostra in vitro e in vivo attivit\u00E0 nei confronti di modelli di policistosi renale e nel cancro pancreatico, ma purtroppo le sue propriet\u00E0 tossicologiche sembrano limitare il suo potenziale terapeutico. \u00C8 in corso uno studio preclinico di un derivato del triptolide, il , un profarmaco sintetico dello stesso."@it . . "Triptolid"@de . . "\u30C8\u30EA\u30D7\u30C8\u30EA\u30C9"@ja . . . "Triptolide"@it . . . . . . "Il triptolide \u00E8 un epossido diterpenoide trovato nella pianta . Mostra in vitro e in vivo attivit\u00E0 nei confronti di modelli di policistosi renale e nel cancro pancreatico, ma purtroppo le sue propriet\u00E0 tossicologiche sembrano limitare il suo potenziale terapeutico. \u00C8 in corso uno studio preclinico di un derivato del triptolide, il , un profarmaco sintetico dello stesso."@it . . . . . . "Triptolide is a diterpenoid epoxide which is produced by the thunder god vine, Tripterygium wilfordii. It has in vitro and in vivo activities against mouse models of polycystic kidney disease and pancreatic cancer, but its physical properties and severe toxicity limit its therapeutic potential. Consequently, a synthetic water-soluble prodrug, minnelide, is being studied clinically instead. Triptolide is a component of ContraPest, a contraceptive pest control liquid used to reduce rat populations in the United States."@en . . . . . "Triptolide.svg"@en . . . . . . "Triptolide is a diterpenoid epoxide which is produced by the thunder god vine, Tripterygium wilfordii. It has in vitro and in vivo activities against mouse models of polycystic kidney disease and pancreatic cancer, but its physical properties and severe toxicity limit its therapeutic potential. Consequently, a synthetic water-soluble prodrug, minnelide, is being studied clinically instead. Triptolide is a component of ContraPest, a contraceptive pest control liquid used to reduce rat populations in the United States."@en . . . . "Triptolide es un ep\u00F3xido diterpenoide producido por la vid del dios del trueno, Tripterygium wilfordii. Tiene actividades in vitro e in vivo contra modelos de rat\u00F3n de enfermedad renal poliqu\u00EDstica\u200B y c\u00E1ncer pancre\u00E1tico, pero sus propiedades f\u00EDsicas\u200B y toxicidad severa\u200B limitan su potencial terap\u00E9utico. En consecuencia, un prof\u00E1rmaco sint\u00E9tico soluble en agua, Minnelide, se est\u00E1 estudiando cl\u00EDnicamente en su lugar.\u200B\u200B"@es . . . . "\u96F7\u516C\u85E4\u5185\u916F\u662F\u4E00\u4E2A\u4E8C\u841C\u7C7B\u73AF\u6C27\u5316\u7269\uFF0C\u5B83\u7531\u96F7\u516C\u85E4\uFF08\u5B66\u540D\uFF1ATripterygium wilfordii\uFF09\u4EA7\u751F\u3002 \u5B83\u5728\u4F53\u5916\u5B9E\u9A8C\u548C\u4F53\u5185\u5B9E\u9A8C\u4E2D\u5BF9\u5C0F\u9F20\u6A21\u578B\u7684\u591A\u56CA\u80BE\u75C5\u548C\u80F0\u817A\u764C\u5177\u6709\u6297\u764C\u4F5C\u7528\uFF0C\u4F46\u662F\u5176\u7269\u7406\u6027\u8D28\u548C\u4E25\u91CD\u7684\u6BD2\u6027\u9650\u5236\u4E86\u5B83\u7684\u6CBB\u7597\u6F5C\u529B\u3002 \u56E0\u6B64\uFF0C\u5408\u6210\u7684\u6C34\u6EB6\u6027\u524D\u4F53\u836F\u7269Minnelide\u6B63\u5728\u8FDB\u884C\u4E34\u5E8A\u4E0A\u7684\u7814\u7A76\u3002"@zh . . "Triptolide es un ep\u00F3xido diterpenoide producido por la vid del dios del trueno, Tripterygium wilfordii. Tiene actividades in vitro e in vivo contra modelos de rat\u00F3n de enfermedad renal poliqu\u00EDstica\u200B y c\u00E1ncer pancre\u00E1tico, pero sus propiedades f\u00EDsicas\u200B y toxicidad severa\u200B limitan su potencial terap\u00E9utico. En consecuencia, un prof\u00E1rmaco sint\u00E9tico soluble en agua, Minnelide, se est\u00E1 estudiando cl\u00EDnicamente en su lugar.\u200B\u200B"@es . . "\u96F7\u516C\u85E4\u5185\u916F\u662F\u4E00\u4E2A\u4E8C\u841C\u7C7B\u73AF\u6C27\u5316\u7269\uFF0C\u5B83\u7531\u96F7\u516C\u85E4\uFF08\u5B66\u540D\uFF1ATripterygium wilfordii\uFF09\u4EA7\u751F\u3002 \u5B83\u5728\u4F53\u5916\u5B9E\u9A8C\u548C\u4F53\u5185\u5B9E\u9A8C\u4E2D\u5BF9\u5C0F\u9F20\u6A21\u578B\u7684\u591A\u56CA\u80BE\u75C5\u548C\u80F0\u817A\u764C\u5177\u6709\u6297\u764C\u4F5C\u7528\uFF0C\u4F46\u662F\u5176\u7269\u7406\u6027\u8D28\u548C\u4E25\u91CD\u7684\u6BD2\u6027\u9650\u5236\u4E86\u5B83\u7684\u6CBB\u7597\u6F5C\u529B\u3002 \u56E0\u6B64\uFF0C\u5408\u6210\u7684\u6C34\u6EB6\u6027\u524D\u4F53\u836F\u7269Minnelide\u6B63\u5728\u8FDB\u884C\u4E34\u5E8A\u4E0A\u7684\u7814\u7A76\u3002"@zh . . "1118207455"^^ . . . . . . . . . . . . "-6"^^ . . "200"^^ . . "(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,9bS)-6-Hydroxy-8b-methyl-6a-(propan-2-yl)-3b,4,4a,5a,6,6a,7a,7b,8a,8b,9,10-dodecahydrotris(oxireno)[2\u2032,3\u2032:4b,5;2\u2032\u2032,3\u2032\u2032:6,7;2\u2032\u2032\u2032,3\u2032\u2032\u2032:8a,9]phenanthro[1,2-c]furan-1(3H)-one"@en . "37364815"^^ . . "\u96F7\u516C\u85E4\u5185\u916F"@zh . . .