Horio Yoshiharu (堀尾 吉晴, 1542 – July 26, 1611) was a Japanese daimyō during the Azuchi–Momoyama and Edo periods. He was appointed to the position of one of san-chūrō (three arbiters) by Toyotomi Hideyoshi along with Ikoma Chikamasa and . He was the first leader of the and also known as Horio Mosuke (堀尾 茂助).