Ōzu Domain (大洲藩, Ōzu-han) was a feudal domain under the Tokugawa shogunate of Edo period Japan, in what is now western Ehime Prefecture on the island of Shikoku. It was centered around Ōzu Castle, and was ruled throughout its history by the tozama daimyō . Ōzu Domain was dissolved in the abolition of the han system in 1871 and is now part of Ehime Prefecture.