The 1921 Lafayette football team was an American football team that represented Lafayette College as an independent during the 1921 college football season. In its third season under head coach Jock Sutherland, Lafayette compiled a perfect 9–0 record, shut out five of its nine opponents, and outscored all opponents by a total of 274 to 26. Significant games included victories over Pittsburgh (6–0), Penn (38–6), and Lehigh (28–6).