The 1964 Hama riot was the first significant clash between the newly installed Ba'ath Party leadership of Syria and the Muslim Brotherhood. It occurred in April 1964, after the 1963 Ba'athist coup d'état. The insurrection was suppressed with heavy military force, resulting in 70-100 mortal casualties and partial destruction of the old Hama city neighborhoods. Hama continued to be a center of Islamists and a focal point of the 1976-1982 Islamist uprising in Syria.