The 2007–08 season in the Honduran Liga Nacional was the 42nd season in the top fight in Honduran football; it ran from August 2007 to May 2008. The season was split into two tournaments (Apertura and Clausura) which defined the 51st and 52nd national champions in the history of the league. C.D. Marathón and Club Deportivo Olimpia as winners of each tournament qualified to the 2008–09 CONCACAF Champions League.