The 2016 Texas A&M–Commerce Lions football team represented Texas A&M University–Commerce as a member of the Lone Star Conference (LSC) during the 2016 NCAA Division II football season. Led by fourth-year head coach Colby Carthel, the Lions compiled an overall record of 11–2 with a mark of 8–1 in conference play, winning the LSC title for the third consecutive season. Texas A&M–Commerce advanced to the NCAA Division II Football Championship playoffs for the fifth time in program history. In the first round, the Lions defeated Colorado Mesa, 34–23, for the program's first playoff win since 1991, but lost to the Grand Valley State, 55–32, in the second round. The Lions were ranked no. 9 in the final AFCA poll.