The 2020–21 Duquesne Dukes men's basketball team represented Duquesne University during the 2020–21 NCAA Division I men's basketball season. The team was led by fourth-year head coach Keith Dambrot, and played their home games at the UPMC Cooper Fieldhouse in Pittsburgh, Pennsylvania and Kerr Fitness Center in McCandless, Pennsylvania as a member of the Atlantic 10 Conference. They finished the season 9-9, 7-7 in A-10 Play to finish in 9th place. They defeated Richmond in the second round of the A-10 tournament before losing in the quarterfinals to St. Bonaventure.