The 2020–21 La Salle Explorers basketball team represented La Salle University during the 2020–21 NCAA Division I men's basketball season. The Explorers, led by third-year head coach Ashley Howard, played their home games at Tom Gola Arena in Philadelphia, Pennsylvania as members of the Atlantic 10 Conference. They finished the season 9-16, 6-11 in A-10 Play to finish in 12th place. They lost in the first round of the A-10 tournament to Saint Joseph’s.