The 2021–22 UNLV Runnin' Rebels basketball team represented the University of Nevada, Las Vegas during the 2021–22 NCAA Division I men's basketball season. The Runnin' Rebels were led by first-year head coach Kevin Kruger and played their home games at the Thomas & Mack Center in Paradise, Nevada as members of the Mountain West Conference. They finished the season 18–14, 10–8 in MWC play to finish in fifth place. They lost to Wyoming in the quarterfinals of the MWC tournament. They failed to receive an invite to a postseason tournament.