The 2021–22 Wyoming Cowboys basketball team represented the University of Wyoming during the 2021–22 NCAA Division I men's basketball season. They were led by Jeff Linder in his second year as head coach at Wyoming. The Cowboys played their home games at the Arena-Auditorium in Laramie, Wyoming as members of the Mountain West Conference. They finished the season 25–9, 13–5 in MWC play to finish in fourth place. They defeated UNLV in the quarterfinals of the MWC tournament before losing to Boise State in the semifinals. They received an at-large bid to the NCAA tournament as a No. 12 seed in the East region where they lost in the First Four to Indiana.