Al-Masmiyya al-Kabira (Arabic: المسمية الكبيرة) was a Palestinian village in the Gaza Subdistrict, located 41 kilometers (25 mi) northeast of Gaza. With a land area of 20,687 dunams, the village site (135 dunams) was situated on an elevation of 75 meters (246 ft) along the coastal plain. It was depopulated during the 1948 Arab–Israeli War. Before the war, it had a population of 2,520 in 1945.