About: Allele-specific oligonucleotide

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An allele-specific oligonucleotide (ASO) is a short piece of synthetic DNA complementary to the sequence of a variable target DNA. It acts as a probe for the presence of the target in a Southern blot assay or, more commonly, in the simpler Dot blot assay. It is a common tool used in genetic testing, forensics, and Molecular Biology research.

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rdfs:label	Allelspezifisches Oligonukleotid (de) Allele-specific oligonucleotide (en)
rdfs:comment	Ein allelspezifisches Oligonukleotid (ASO) ist eine kurze, meist synthetische DNA, die in der Biochemie und Molekularbiologie zur Unterscheidung von Einzelnukleotid-Polymorphismen verwendet wird. (de) An allele-specific oligonucleotide (ASO) is a short piece of synthetic DNA complementary to the sequence of a variable target DNA. It acts as a probe for the presence of the target in a Southern blot assay or, more commonly, in the simpler Dot blot assay. It is a common tool used in genetic testing, forensics, and Molecular Biology research. (en)
foaf:depiction
dcterms:subject	DNA profiling techniques Molecular biology Molecular biology techniques Laboratory techniques
Wikipage page ID	10099472 (xsd:integer)
Wikipage revision ID	1077618128 (xsd:integer)
Link from a Wikipage to another Wikipage	Messenger RNA Mutation Nucleotide Allele DNA profiling techniques Restriction Enzyme DNA Valine Dot blot Polymerase chain reaction Nucleic acid hybridization Genetic testing Genotype Oligonucleotide Zygosity Genetic carrier Molecular Biology Multiple myeloma dbr:Thymine Codon dbr:Adenine Amino acid Molecular biology Molecular biology techniques DNA sequencing Duarte, California Forensics HBB Hybridization probe Laboratory techniques City of Hope National Medical Center Human Genome Project Dominance relationship Minimal residual disease Single-nucleotide polymorphism Sickle-cell disease Illumina Methylation Assay Variants of PCR Oligomer restriction Autoradiography Restriction Fragment Length Polymorphism Southern blot Glutamate
Link from a Wikipage to an external page	https://www.mun.ca/biology/scarr/ASO_test_for_CF2.html
sameAs	Allele-specific oligonucleotide Allele-specific oligonucleotide Allele-specific oligonucleotide Allele-specific oligonucleotide Allele-specific oligonucleotide
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thumbnail	wiki-commons:Special:FilePath/Allele-specific_oligonucleotide_(sample).jpg?width=300
has abstract	An allele-specific oligonucleotide (ASO) is a short piece of synthetic DNA complementary to the sequence of a variable target DNA. It acts as a probe for the presence of the target in a Southern blot assay or, more commonly, in the simpler Dot blot assay. It is a common tool used in genetic testing, forensics, and Molecular Biology research. An ASO is typically an oligonucleotide of 15–21 nucleotide bases in length. It is designed (and used) in a way that makes it specific for only one version, or allele, of the DNA being tested. The length of the ASO, which strand it is chosen from, and the conditions by which it is bound to (and washed from) the target DNA all play a role in its specificity. These probes can usually be designed to detect a difference of as little as 1 base in the target's genetic sequence, a basic ability in the assay of single-nucleotide polymorphisms (SNPs), important in genotype analysis and the Human Genome Project. To be detected after it has bound to its target, the ASO must be labeled with a radioactive, enzymatic, or fluorescent tag. The Illumina Methylation Assay technology takes advantage of ASO to detect one base pair difference (cytosine versus thymine) to measure methylation at a specific CpG site. (en) Ein allelspezifisches Oligonukleotid (ASO) ist eine kurze, meist synthetische DNA, die in der Biochemie und Molekularbiologie zur Unterscheidung von Einzelnukleotid-Polymorphismen verwendet wird. (de)
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prov:wasDerivedFrom	wikipedia-en:Allele-specific_oligonucleotide?oldid=1077618128&ns=0
page length (characters) of wiki page	9810 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Allele-specific_oligonucleotide
is Link from a Wikipage to another Wikipage of	Huntington's disease Gene therapy Cleaved amplified polymorphic sequence ASO Human genetic enhancement Illumina Methylation Assay Molecular biology SNP array SNP genotyping Restriction fragment length polymorphism Allele Specific Oligonucleotide (ASO) Allele specific oligonucleotide Allele specific oligonucleotides
is Wikipage redirect of	Allele Specific Oligonucleotide (ASO) Allele specific oligonucleotide Allele specific oligonucleotides
is Wikipage disambiguates of	ASO
is foaf:primaryTopic of	wikipedia-en:Allele-specific_oligonucleotide

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