About: Cortico-basal ganglia-thalamo-cortical loop

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The cortico-basal ganglia-thalamo-cortical loop (CBGTC loop) is a system of neural circuits in the brain. The loop involves connections between the cortex, the basal ganglia, the thalamus, and back to the cortex. It is of particular relevance to hyperkinetic and hypokinetic movement disorders, such as Parkinson's disease and Huntington's disease, as well as to mental disorders of control, such as attention deficit hyperactivity disorder (ADHD), obsessive–compulsive disorder (OCD), and Tourette syndrome.

Attributes	Values
rdf:type	Thing wikidata:Q4936952 anatomical structure brain
rdfs:label	Cortico-basal ganglia-thalamo-cortical loop (en)
rdfs:comment	The cortico-basal ganglia-thalamo-cortical loop (CBGTC loop) is a system of neural circuits in the brain. The loop involves connections between the cortex, the basal ganglia, the thalamus, and back to the cortex. It is of particular relevance to hyperkinetic and hypokinetic movement disorders, such as Parkinson's disease and Huntington's disease, as well as to mental disorders of control, such as attention deficit hyperactivity disorder (ADHD), obsessive–compulsive disorder (OCD), and Tourette syndrome. (en)
foaf:name	Cortico-basal ganglia-thalamo-cortical loop (en)
name	Cortico-basal ganglia-thalamo-cortical loop (en)
foaf:depiction
dct:subject	Neuroanatomy
Wikipage page ID	52876404 (xsd:integer)
Wikipage revision ID	1105090207 (xsd:integer)
Link from a Wikipage to another Wikipage	Subthalamic nucleus Deep brain stimulation Huntington's disease Dopamine receptor D1 Dopamine receptor D2 Dopaminergic Indirect pathway Mental disorder Chemical synapse Substantia nigra Putamen Brain Consciousness Frontal eye fields Muscarinic acetylcholine receptor M1 Muscarinic acetylcholine receptor M4 Neuroanatomy Adenosine A1 receptor Adenosine A2A receptor Cerebrum Tourette syndrome Basal ganglia Parkinson's disease Caudate nucleus Direct pathway Globus pallidus Motor cortex Pars compacta Obsessive–compulsive disorder Hyperkinesia Hypokinesia Somatosensory cortex Attention deficit hyperactivity disorder Cerebral cortex Supplementary motor area Ventral tegmental area Neural circuit Movement disorder Thalamus Intrusive thoughts Striatum Systems neuroscience Glutamate Parietal cortex
sameAs	Cortico-basal ganglia-thalamo-cortical loop Cortico-basal ganglia-thalamo-cortical loop
dbp:wikiPageUsesTemplate	dbt:Infobox_brain dbt:Further dbt:Reflist dbt:Short_description dbt:Technical
thumbnail	wiki-commons:Special:FilePath/Basal_ganglia_circuits.svg?width=300
caption	Connections of the basal ganglia. (en)
has abstract	The cortico-basal ganglia-thalamo-cortical loop (CBGTC loop) is a system of neural circuits in the brain. The loop involves connections between the cortex, the basal ganglia, the thalamus, and back to the cortex. It is of particular relevance to hyperkinetic and hypokinetic movement disorders, such as Parkinson's disease and Huntington's disease, as well as to mental disorders of control, such as attention deficit hyperactivity disorder (ADHD), obsessive–compulsive disorder (OCD), and Tourette syndrome. The CBGTC loop primarily consists of modulatory dopaminergic projections from the pars compacta of the substantia nigra, and ventral tegmental area as well as excitatory glutamatergic projections from the cortex to the striatum, where these projections form synapses with excitatory and inhibitory pathways that relay back to the cortex. The loop was originally proposed as a part of a model of the basal ganglia called the parallel processing model, which has been criticized and modified into another model called the center surround model. Current organization schemes characterize cortico-basal ganglia interactions as segregated parallel processing, meaning there is little convergence of distinct cortical areas in the basal ganglia. This is thought to explain the topographically organized functionality of the striatum. The striatum is organized on a rostro-caudal axis, with the rostral putamen and caudate serving associative and cognitive functions and the caudal areas serving sensorimotor function. Sometimes when the striatum is the expressed target the loop is referred to as the cortico-striatal-thalamic-cortical loop. (en)
IsPartOf	Cerebrum
is part of anatomical structure	Cerebrum
prov:wasDerivedFrom	wikipedia-en:Cortico-basal_ganglia-thalamo-cortical_loop?oldid=1105090207&ns=0
page length (characters) of wiki page	14749 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Cortico-basal_ganglia-thalamo-cortical_loop
is Link from a Wikipage to another Wikipage of	Orbitofrontal cortex Primate basal ganglia Cortico-striatal-thalamic-cortical loop Dopaminergic pathways Neural pathway Tourette syndrome Gamma wave Cortico-striato-cortical loop Dystonia Basal ganglia Nucleus accumbens Cause of obsessive-compulsive disorder Direct pathway Glutamate hypothesis of schizophrenia Obsessive–compulsive disorder Reward system Biology of depression Biology of obsessive–compulsive disorder Salience network CSTC Neural circuit dbr:FOXP2 Striatum
is Wikipage redirect of	Cortico-striatal-thalamic-cortical loop Cortico-striato-cortical loop
is foaf:primaryTopic of	wikipedia-en:Cortico-basal_ganglia-thalamo-cortical_loop

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