About: Dmitry Gabrilovich

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Dmitry Gabrilovich is currently a Chief Scientist, Cancer Immunology at AstraZeneca in Gaithersburg, MD, USA. His research is focused on methods by which tumors are able to suppress the immune system and how to develop new immune therapies to combat this ability. Gabrilovich described the defective ability of dendritic cells in induce immune responses in cancer, and was one of the discoverers of myeloid-derived suppressor cells (MDSC). The Gabrilovich lab focuses on immature myeloid cell biology and its relation to cancer. MDSC have been linked to a number of signaling pathways associated with cancer, including NF-κB, Jak-STAT, Notch, Wnt, and Rb, among others. His research has found that tumor cells can go through a mechanism that produces a free radical peroxynitrite, causing them to bec

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rdfs:label	Dmitry Gabrilovich (en)
rdfs:comment	Dmitry Gabrilovich is currently a Chief Scientist, Cancer Immunology at AstraZeneca in Gaithersburg, MD, USA. His research is focused on methods by which tumors are able to suppress the immune system and how to develop new immune therapies to combat this ability. Gabrilovich described the defective ability of dendritic cells in induce immune responses in cancer, and was one of the discoverers of myeloid-derived suppressor cells (MDSC). The Gabrilovich lab focuses on immature myeloid cell biology and its relation to cancer. MDSC have been linked to a number of signaling pathways associated with cancer, including NF-κB, Jak-STAT, Notch, Wnt, and Rb, among others. His research has found that tumor cells can go through a mechanism that produces a free radical peroxynitrite, causing them to bec (en)
foaf:name	Dmitry Gabrilovich (en)
name	Dmitry Gabrilovich (en)
birth place	Minsk, USSR
birth place	Minsk, USSR
birth date	1961-05-24 (xsd:date)
dct:subject	1954 births Living people Cancer researchers
Wikipage page ID	41969025 (xsd:integer)
Wikipage revision ID	1025237430 (xsd:integer)
Link from a Wikipage to another Wikipage	Tumors 1954 births Living people Cancer researchers Tampa Philadelphia Moffitt Cancer Center Myeloid-derived suppressor cell Myeloid The Wistar Institute Minsk, USSR
Link from a Wikipage to an external page	http://www.nature.com/articles/nm1096-1096%7Cjournal=Nature
sameAs	Dmitry Gabrilovich Dmitry Gabrilovich Dmitry Gabrilovich Dmitry Gabrilovich
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birth date	1961-05-24 (xsd:date)
occupation	Researcher, professor (en)
years active	1984 (xsd:integer)
has abstract	Dmitry Gabrilovich is currently a Chief Scientist, Cancer Immunology at AstraZeneca in Gaithersburg, MD, USA. His research is focused on methods by which tumors are able to suppress the immune system and how to develop new immune therapies to combat this ability. Gabrilovich described the defective ability of dendritic cells in induce immune responses in cancer, and was one of the discoverers of myeloid-derived suppressor cells (MDSC). The Gabrilovich lab focuses on immature myeloid cell biology and its relation to cancer. MDSC have been linked to a number of signaling pathways associated with cancer, including NF-κB, Jak-STAT, Notch, Wnt, and Rb, among others. His research has found that tumor cells can go through a mechanism that produces a free radical peroxynitrite, causing them to become resistant to certain types of cancer immunotherapy. His research has also focused on monocytic-myeloid derived suppressor cells and polymorphonuclear-myeloid derived suppressor cells and what impact they might have on cancer therapy, since myeloid derived suppressor cells negatively regulate anti-tumor activity. His group described methods of targeting suppressive myeloid cell.In 2019 he was awarded title of Research Professor by American Cancer Society.Prior to joining AstraZeneca, Gabrilovich was a researcher and Christopher M. Davis professor at The Wistar Institute in Philadelphia. Prior to joining The Wistar Institute, Gabrilovich was a senior member at the Moffitt Cancer Center in Tampa. (en)
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active years end year	1984-01-01 (xsd:gYear)
active years start year	1984-01-01 (xsd:gYear)
birth year	1961-01-01 (xsd:gYear)
occupation	dbr:Dmitry_Gabrilovich__PersonFunction__1
foaf:isPrimaryTopicOf	wikipedia-en:Dmitry_Gabrilovich
is Link from a Wikipage to another Wikipage of	Myeloid-derived suppressor cell
is foaf:primaryTopic of	wikipedia-en:Dmitry_Gabrilovich

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