Sir Francis Weston KB (1511 – 17 May 1536) was a gentleman of the Privy Chamber at the court of King Henry VIII of England. He became a friend of the king but was later accused of high treason and adultery with Anne Boleyn, the king's second wife. Weston was condemned to death, together with George Boleyn, Viscount Rochford, Henry Norris, William Brereton and Mark Smeaton. They were all executed on 17 May 1536, two days before Anne Boleyn suffered a similar fate.