George Escol Sellers (November 26, 1808 – January 1, 1899) was an American businessman, mechanical engineer, and inventor. He owned and managed different businesses and patented several inventions. He established a company with his brother Charles where he patented his early invention of a machine that produced lead pipes from hot fluid lead continuously. While working for the Panama Railway in the 1850s, he received various patents for improvements he made on railroad locomotives, including a railroad engine which could climb steep hills.