About: Infologs

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Infologs are independently designed synthetic genes derived from one or a few genes where substitutions are systematically incorporated to maximize information. Infologs are designed for perfect diversity distribution to maximize search efficiency.

Attributes	Values
rdfs:label	Infologs (en)
rdfs:comment	Infologs are independently designed synthetic genes derived from one or a few genes where substitutions are systematically incorporated to maximize information. Infologs are designed for perfect diversity distribution to maximize search efficiency. (en)
foaf:depiction
dct:subject	Bioinformatics Protein engineering
Wikipage page ID	37760976 (xsd:integer)
Wikipage revision ID	1042126229 (xsd:integer)
Link from a Wikipage to another Wikipage	Bioinformatics OrthoDB Horizontal gene transfer Synthetic biology Glutathione S-transferase Protein folding Homology (biology) Artificial gene synthesis Algorithms Protein engineering Protein engineering Site-directed mutagenesis
Link from a Wikipage to an external page	https://www.dna20.com/services/proteingps https://www.dna20.com/wp-content/uploads/2012/07/EnzEngrXXI_2011_Final.pdf https://www.dna20.com/wp-content/uploads/2014/07/GRC_Biocatalysis_ProteinGPS_Poster_072014.pdf http://authors.library.caltech.edu/14455/1/Heinzelman2009p1637P_Natl_Acad_Sci_Usa.pdf
sameAs	Infologs Infologs Infologs
dbp:wikiPageUsesTemplate	dbt:Cite_journal dbt:Main dbt:Multiple_image dbt:Orphan dbt:Reflist
thumbnail	wiki-commons:Special:FilePath/Infologs,_show_full_diversity_distribution_of_space.png?width=300
align	center (en)
caption	Infologs: Independently designed synthetic genes derived from one or a few genes where substitutions are systematically incorporated to maximize information. Infologs are designed for perfect diversity distribution to maximize search efficiency. (en) Homologs: Naturally occurring genes that share common ancestry and traits. Diversity is biased and non-systematic. (en)
footer	Comparison of Homologs and Infologs (en)
image	Homologs.png (en) Wheat GST Infologs.jpg (en)
has abstract	Infologs are independently designed synthetic genes derived from one or a few genes where substitutions are systematically incorporated to maximize information. Infologs are designed for perfect diversity distribution to maximize search efficiency. Typical protein engineering methods rely on screening a high number (106-1012 or more) of gene variants to identify individuals with improved activity using a surrogate high throughput screen (HTP) to identify initial hits. Unfortunately, results are defined by what is screened for, thus the “hit” from the HTP screen often has very little real activity in a lower throughput assay more indicative of the improved functionality for which the protein is being developed. By adapting the standard algorithms for engineering complex systems to work with biological systems, the resulting process enables researchers to deconvolute how substitutions within a protein sequence modify its function. Combining these algorithms with an integrated query and ranking mechanism allows the identification of appropriate sequence substitutions. Infologs refers to the set of designed genes, singular use Infolog describes an individual variant. (en)
prov:wasDerivedFrom	wikipedia-en:Infologs?oldid=1042126229&ns=0
page length (characters) of wiki page	11434 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Infologs
is foaf:primaryTopic of	wikipedia-en:Infologs

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