Maryland Route 222 (MD 222) is a state highway in the U.S. state of Maryland. The highway runs 11.36 miles (18.28 km) from MD 7 in Perryville north to U.S. Route 1 (US 1) near Conowingo. MD 222 connects Perryville, Port Deposit, and Conowingo along its route paralleling the Susquehanna River in western Cecil County. Due to limitations in the highway in Port Deposit, including a steep hill and a low-clearance railroad bridge, trucks are directed to use MD 275, MD 276, and US 1 through Woodlawn and Rising Sun to connect Interstate 95 (I-95) with US 222 in Conowingo.