Md Isa Sabu (born 24 August 1946) was the seventh Chief Minister of the Malaysian state of Perlis, in office from 2008 to 2013. He is a member of the United Malays National Organisation (UMNO). He held the state assembly seat of Bintong, in the Perlis capital of Kangar, until his retirement from politics in 2013. Md Isa is married with seven children. He was member of the federal parliament for Kangar from 1995 to 1999.