The National Tainan Second Senior High School (TNSSH; Chinese: 國立臺南第二高級中學) is a senior high school in North District, Tainan, Taiwan. It was established in May 1914 during the period of Japanese rule. It was the first senior high school in middle and southern Taiwan. The school is one of the most prestigious high schools in the city. As for the recent high school entry exam, which is mandatory for a student in Taiwan for attending high school, a student must have the top 10-11% mark in the test in order to gain admission to the school.