About: Nonsynonymous substitution

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A nonsynonymous substitution is a nucleotide mutation that alters the amino acid sequence of a protein. Nonsynonymous substitutions differ from synonymous substitutions, which do not alter amino acid sequences and are (sometimes) silent mutations. As nonsynonymous substitutions result in a biological change in the organism, they are subject to natural selection. Nonsynonymous substitutions are also referred to as replacement mutations.

Attributes	Values
rdf:type	bird
rdfs:label	استبدال لاترادفي (ar) Nonsynonymous substitution (en) Mutações não sinônimas (pt)
rdfs:comment	الاِسْتِبْدَال اللاَّتَرَادُفِيّ (بالإنجليزية: nonsynonymous substitution)‏ هو في علم الوراثيات، استبدال قاعدة بأخرى في يخروج مورثة مشفّر لبروتين، وهي ما يؤدي إلى تغير تسلسل الأحماض الأمينية المنتجة. (ar) A nonsynonymous substitution is a nucleotide mutation that alters the amino acid sequence of a protein. Nonsynonymous substitutions differ from synonymous substitutions, which do not alter amino acid sequences and are (sometimes) silent mutations. As nonsynonymous substitutions result in a biological change in the organism, they are subject to natural selection. Nonsynonymous substitutions are also referred to as replacement mutations. (en) Uma substituição não-sinônima é uma mutação de nucleotídeo que altera a sequência de aminoácidos de uma proteína . As substituições não- sinônimas diferem das substituições sinônimas, que não alteram as sequências de aminoácidos e são (às vezes) mutações silenciosas . Como as substituições não sinônimas resultam em uma mudança biológica no organismo, elas estão sujeitas à seleção natural . (pt)
dcterms:subject	Molecular biology Mutation
Wikipage page ID	25664757 (xsd:integer)
Wikipage revision ID	1102373157 (xsd:integer)
Link from a Wikipage to another Wikipage	Mutation Nucleotide Genetic drift Natural selection Neutral theory of molecular evolution Nonsense mutation Silent mutation Point mutation Stop codon Synonymous substitution Amino acid Molecular biology Ka/Ks ratio Protein Mutation Missense mutation McDonald–Kreitman test Molecular evolution
Link from a Wikipage to an external page	http://mbe.library.arizona.edu/data/1986/0305/4nei.pdf http://serine.umiacs.umd.edu/teaching/molecular_evolution_ugrad/syllabus/files/synonymous_non-synonymous_471.pdf
sameAs	Nonsynonymous substitution Nonsynonymous substitution Nonsynonymous substitution Nonsynonymous substitution Nonsynonymous substitution Nonsynonymous substitution Nonsynonymous substitution
dbp:wikiPageUsesTemplate	dbt:MolBioGeneExp dbt:Reflist dbt:Short_description dbt:MolecularEvolution dbt:Mutation
has abstract	الاِسْتِبْدَال اللاَّتَرَادُفِيّ (بالإنجليزية: nonsynonymous substitution)‏ هو في علم الوراثيات، استبدال قاعدة بأخرى في يخروج مورثة مشفّر لبروتين، وهي ما يؤدي إلى تغير تسلسل الأحماض الأمينية المنتجة. (ar) A nonsynonymous substitution is a nucleotide mutation that alters the amino acid sequence of a protein. Nonsynonymous substitutions differ from synonymous substitutions, which do not alter amino acid sequences and are (sometimes) silent mutations. As nonsynonymous substitutions result in a biological change in the organism, they are subject to natural selection. Nonsynonymous substitutions at a certain locus can be compared to the synonymous substitutions at the same locus to obtain the Ka/Ks ratio. This ratio is used to measure the evolutionary rate of gene sequences. If a gene has lower levels of nonsynonymous than synonymous nucleotide substitution, then it can be inferred to be functional because a Ka/Ks ratio < 1 is a hallmark of sequences that are being constrained to code for proteins. Nonsynonymous substitutions are also referred to as replacement mutations. (en) Uma substituição não-sinônima é uma mutação de nucleotídeo que altera a sequência de aminoácidos de uma proteína . As substituições não- sinônimas diferem das substituições sinônimas, que não alteram as sequências de aminoácidos e são (às vezes) mutações silenciosas . Como as substituições não sinônimas resultam em uma mudança biológica no organismo, elas estão sujeitas à seleção natural . Substituições não-sinônimas em certos loci podem ser comparadas às substituições sinônimas nesses loci para obter a razão K. Essa proporção é usada para medir a taxa evolutiva de sequências de genes. Se um gene tem níveis mais baixos de substituição de nucleotídeos não-sinônima do que sinônima, então ele pode ser inferido como funcional porque uma razão Ka/ Ks é uma marca registrada de sequências que estão sendo restritas a codificar proteínas. Substituições não-sinônimas também são chamadas de mutações de substituição . (pt)
gold:hypernym	Mutation
prov:wasDerivedFrom	wikipedia-en:Nonsynonymous_substitution?oldid=1102373157&ns=0
page length (characters) of wiki page	8360 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Nonsynonymous_substitution
is Link from a Wikipage to another Wikipage of	Mutation Nonsynonymous Nonsynonymous mutations Substitution model OR10G4 Conotoxin Overlapping gene Silent mutation Glossary of genetics Glossary of genetics (M−Z) Synonymous substitution Adaptive evolution in the human genome Ka/Ks ratio Killer-cell immunoglobulin-like receptor Missense mRNA Missense mutation Cadherin related family member 3 Single-nucleotide polymorphism Neurogenetics Nonsynonymous variant TMEM39B Rate of evolution
is Wikipage redirect of	Nonsynonymous Nonsynonymous mutations Nonsynonymous variant
is foaf:primaryTopic of	wikipedia-en:Nonsynonymous_substitution

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