Oregon Route 99E is an Oregon state highway that runs between Junction City, Oregon and an interchange with I-5 just south of the Oregon/Washington border, in Portland. It, along with OR 99W, makes up a split of OR 99 in the northern part of the state. This split existed when the route was U.S. Route 99, when the two branches were U.S. 99W and U.S. 99E. (Another such split occurred in California, but with the decommissioning of U.S. 99, that state elected to rename its U.S. 99W as Interstate 5, rather than preserve the directional suffix.)