Quassinoids are degraded triterpene lactones (similar to limonoids) of the Simaroubaceae plant family grouped into C-18, C-19, C-20, C-22 and C-25 types. The prototypical member of the group, quassin, was first described in the 19th century from plants of the genus Quassia from which it gets its name. It was isolated in 1937 and its structure elucidated in 1961. Other quassinoids include:
* Bruceanols
* Bruceolide
* Eurycomanone
* Gutolactone
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| - Quasinoide (es)
- Quassinoid (en)
- Quassinoid (zh)
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| - Quasinoides son un grupo de compuestos químicos naturales clasificados como triterpenoides. Son principios amargos que se encuentran en las plantas en la familia Simaroubaceae. El prototipo miembro del grupo, Cuasina, fue aislado por primera vez en el siglo XIX a partir de las plantas del género Quassia de la que toma su nombre. Otros Quasinoides son:
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* (es)
- Quassinoids是苦木科 (Simaroubaceae) 東格阿里屬 (Eurycoma) 植物萃取物降解的三萜內酯（類似於檸檬苦素），分為C-18，C-19，C-20，C-22和C-25類型。 該類型首次於19世紀 Quassia 屬中的一員 quassin 被發現和記錄，並由此作為命名。並於1937年被單獨從植物萃取物中分離出來,而後在1961年對其進行分析和紀錄其特性。 此三萜內酯類為具有生物活性的天然產物，具有顯著的抗癌,抗發炎,和抑制瘧疾的功效，重而引起了藥學界的廣泛關注。分別在1982年和1983年對 quassinoid bruceantin 其論證兩項各自獨立的II期臨床試驗，雖然上世紀80年代被認為對細胞有毒性,但進入21世紀後開始有藥學專家開始對 Quassinoids 其進行先導藥物開發研究工作.闡明其具有優秀的藥用製備潛力,並於2020年開展研究導入類標靶式方法,嘗試開發針對特定病毒,防止病毒其本身蛋白質轉錄(從DNA模板合成RNA的現象)的抑制劑。 (zh)
- Quassinoids are degraded triterpene lactones (similar to limonoids) of the Simaroubaceae plant family grouped into C-18, C-19, C-20, C-22 and C-25 types. The prototypical member of the group, quassin, was first described in the 19th century from plants of the genus Quassia from which it gets its name. It was isolated in 1937 and its structure elucidated in 1961. Other quassinoids include:
* Bruceanols
* Bruceolide
* Eurycomanone
* Gutolactone
*
*
*
*
*
* (en)
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| - Quasinoides son un grupo de compuestos químicos naturales clasificados como triterpenoides. Son principios amargos que se encuentran en las plantas en la familia Simaroubaceae. El prototipo miembro del grupo, Cuasina, fue aislado por primera vez en el siglo XIX a partir de las plantas del género Quassia de la que toma su nombre. Otros Quasinoides son:
*
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* (es)
- Quassinoids are degraded triterpene lactones (similar to limonoids) of the Simaroubaceae plant family grouped into C-18, C-19, C-20, C-22 and C-25 types. The prototypical member of the group, quassin, was first described in the 19th century from plants of the genus Quassia from which it gets its name. It was isolated in 1937 and its structure elucidated in 1961. They are a biologically potent class of natural products, possessing antimalarial, antifeedant, insecticidal, anti-inflammatory, and anticancer properties. The quassinoid bruceantin reached two separate phase II clinical trials in 1982 and 1983. Other quassinoids include:
* Bruceanols
* Bruceolide
* Eurycomanone
* Gutolactone
*
*
*
*
*
* (en)
- Quassinoids是苦木科 (Simaroubaceae) 東格阿里屬 (Eurycoma) 植物萃取物降解的三萜內酯（類似於檸檬苦素），分為C-18，C-19，C-20，C-22和C-25類型。 該類型首次於19世紀 Quassia 屬中的一員 quassin 被發現和記錄，並由此作為命名。並於1937年被單獨從植物萃取物中分離出來,而後在1961年對其進行分析和紀錄其特性。 此三萜內酯類為具有生物活性的天然產物，具有顯著的抗癌,抗發炎,和抑制瘧疾的功效，重而引起了藥學界的廣泛關注。分別在1982年和1983年對 quassinoid bruceantin 其論證兩項各自獨立的II期臨床試驗，雖然上世紀80年代被認為對細胞有毒性,但進入21世紀後開始有藥學專家開始對 Quassinoids 其進行先導藥物開發研究工作.闡明其具有優秀的藥用製備潛力,並於2020年開展研究導入類標靶式方法,嘗試開發針對特定病毒,防止病毒其本身蛋白質轉錄(從DNA模板合成RNA的現象)的抑制劑。 (zh)
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