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About: Raphe nuclei     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:Thing100002452, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thinglanguagewikidata:Q4936952anatomical structurebrainyago:BodyPart105220461yago:Brain105481095yago:NeuralStructure105462674yago:Part109385911yago:PhysicalEntity100001930yago:Structure105225602yago:Thing100002452 New Facet based on Instances of this Class

The raphe nuclei (Greek: ῥαφή, "seam") are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with Gi/Go-protein-inhibiting adenyl cyclase. They function as autoreceptors in the brain and decrease the release of serotonin. The anxiolytic drug Buspirone acts as partial agonist against these receptors. Selective serotonin reuptake inhibitor (SSRI) antidepressants are believed to act in these nuclei, as well as at their targets.