Tiruvengimalai Sesha Sundara Rajan (1880–1953) was an Indian doctor, politician and freedom-fighter who served the Minister of Public Health and Religious Endowments in the Madras Presidency from 1937 to 1939. Rajan was born in Srirangam in Trichinopoly district and studied medicine at Royapuram Medical School, Madras and England. He practised as a doctor in Burma and England and obtained his M.R.C.S. degree in 1911. In 1923, he set up his own clinic.