The Little Sister is a 1949 novel by Raymond Chandler, his fifth featuring the private investigator Philip Marlowe. The story is set in Los Angeles in the late 1940s and follows Marlowe's investigation of a missing persons case and blackmail scheme centered around a Hollywood starlet. With several scenes involving the film industry, the novel was partly inspired by Chandler's experience working as a screenwriter in Hollywood and his low opinion of the industry and most of the people in it. The book was first published in the UK in June 1949 and was released in the United States three months later.