U.S. Route 422 Business (US 422 Bus.) is a 7.29-mile-long (11.73 km) business route of US 422 located in the Reading, Pennsylvania area. The route is one of four auxiliary routes of US 422 in Pennsylvania. Its western terminus is at an interchange with US 222 and US 422 in Wyomissing. Its eastern terminus is at an interchange with US 422 in Reiffton. US 422 Bus. heads east from US 222/US 422 along Penn Avenue, passing through Wyomissing and West Reading. The route has an interchange with the US 422 freeway before it crosses the Schuylkill River into Reading. US 422 Bus. passes through downtown Reading on the one-way pair of Franklin Street eastbound and Washington Street westbound, intersecting the southern terminus of Pennsylvania Route 183 (PA 183) and crossing US 222 Bus. The business r