USS Benson (DD-421) was the lead ship of her class of destroyers in the United States Navy during World War II. She was named for Admiral William S. Benson (1855–1932). Benson was laid down on 16 May 1938 at Quincy, Mass., by the Bethlehem Steel Co.; launched on 15 November 1939; sponsored by Mrs. William S. Benson, the widow of Adm. Benson; and commissioned on 25 July 1940.