The first USS McCook (DD-252) was a Clemson-class destroyer in the United States Navy. Entering service in 1919, the ship had a brief active life before being placed in the reserve fleet. Reactivated for World War II, the ship was transferred to the Royal Navy and then to the Royal Canadian Navy and renamed HMCS St. Croix. Assigned as a convoy escort in the Battle of the Atlantic, St. Croix was torpedoed and sunk on 20 September 1943.