The 2010 CIS Men's University Cup Hockey Tournament (48th Annual) was held March 25–28, 2010. It was the second year of a two-year CIS Championship bid by Lakehead University and hosted at Fort William Gardens hockey rink. The UNB Varsity Reds would not be defending their title from 2009, despite a 27-1 record, as they lost in the second round of the AUS playoffs and did not advance. The Saint Mary's Huskies won their first Hockey title in school history with a dramatic 3–2 overtime win versus the #1 seed Alberta Golden Bears who were looking for their 14th.