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About: SCO1     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:Series108457976, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: ThingBiomoleculegeneBiomoleculeGeneyago:Abstraction100002137yago:Arrangement107938773yago:Gene105436752yago:Group100031264yago:Ordering108456993yago:WikicatGenesMutatedInMiceHumanGeneproteinyago:Sequence108459252yago:Series108457976 New Facet based on Instances of this Class

Protein SCO1 homolog, mitochondrial, also known as SCO1, cytochrome c oxidase assembly protein, is a protein that in humans is encoded by the SCO1 gene. SCO1 localizes predominantly to blood vessels, whereas SCO2 is barely detectable, as well as to tissues with high levels of oxidative phosphorylation. The expression of SCO2 is also much higher than that of SCO1 in muscle tissue, while SCO1 is expressed at higher levels in liver tissue than SCO2. Mutations in both SCO1 and SCO2 are associated with distinct clinical phenotypes as well as tissue-specific cytochrome c oxidase (complex IV) deficiency.