Isaac Sterling "Ike" Struble (November 3, 1843 – February 17, 1913) was an American politician who was a four-term Republican Representative of Iowa's 11th congressional district. Serving from 1883 to 1891, the Plymouth County resident was a noted congressional opponent of plural marriage in the Utah Territory. The member of a politically active family, Isaac's six brothers included John T. Struble of Iowa, and George R. Struble, former speaker of the Iowa House of Representatives. He was the granduncle of Bob Struble, Sr. and great-granduncle of Bob Struble, Jr.