William Francis Clarke (March 19, 1816 – October 17, 1890) was an American Catholic priest and Jesuit who held several senior positions at Jesuit institutions in Maryland and Washington, D.C. Born in Washington, he descended from several early colonial families of Maryland. He was educated at Gonzaga College and its successor institutions during the suppression of the Society of Jesus, followed by Georgetown College. After his entrance into the Jesuit order, he taught for several years at Georgetown, and became the pastor of St. Joseph's Church in Baltimore, where he took uncommon measures to integrate black Catholics and Italian immigrants into parish life.